期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

长效生长抑素类似物治疗消化系统肿瘤新进展 被引量：1

New advance in treatmet of digestive tumors using long-acting somatostatin analogues
下载PDF
导出
摘要 生长抑素(somatostatin,SS)广泛存在于人体各种正常组织,具有抑制性生理功能,共有5种SS受体亚型,肿瘤组织亦表达不同的SS受体。SS类似物在治疗胃肠和胰腺内分泌肿瘤中起重要作用,近年来很多研究表明SS类似物对治疗非内分泌性、实体性肿瘤可能同样有效。长效生长抑素类似物如长效奥曲肽(octreotide)和兰瑞肽(lanreotide)两种剂型,能与SS受体亚型-2(SSR2)、受体亚型-5(SSR-5)结合,维持长期稳定的血浆药物浓度,产生持久的抑制多种激素分泌作用。现就近年来长效生长抑素类似物治疗消化系统肿瘤新进展做一综述。 Somatostatin known as somatotropin release-inhibiting factor, mediates its actions via five different receptors. Somatostatin receptors also present in various tumor issue.Two long-acting somatostatin analogues, octreotide and lanreotide, are recognized by the receptor subtypes 2 and 5. Long-acting somatostatin analogues are used clinically for treatment of neuroendocrine gastroenteropancreatic tumors and have become first-line drugs for controlling hormone-mediated symptoms of carcinoid tumors. In the present study many data show clinical potentia of long-acting somatostatin analogues in treatment of digestive tumors.
作者 黄海波 吴本俨
机构地区 解放军总医院老年消化科
出处 《中国新药杂志》 CAS CSCD 北大核心 2004年第5期392-395,共4页 Chinese Journal of New Drugs
关键词 生长抑素 长效生长抑素类似物 消化系统肿瘤 somatostatin long-acting somatostatin anologues digestive tumors
分类号 R977.1 [医药卫生—药品] R735 [医药卫生—肿瘤]
  • 相关文献

参考文献24

  • 1Strowski MZ,Parmar RM,Blake AD,et al.Somatostatin inhibits insulin and glucagon secretion via two receptors subtypes:an in vitro study of pancreatic islets from somatostatin receptor 2 knockout mice[J].Endocrinology,2000,141(3)∶111-117.
  • 2Lopez F,Ferjoux G,Cordelier P,et al.Neuronal nitric oxide synthase:a substrate for SHP-1 involved in sst2 somatostatin receptor growth inhibitory signaling[J].FASEB J,2001,15(5):2300-2302.
  • 3Ferjoux G,Bousquet C,Cordelier P,et al.Signal transduction of somatostatin receptors negatively controlling cell proliferation[J].J Physiol Paris,2000,94(7):205-210.
  • 4Vantus T,Keri G,Krivickiene Z,et al.The somatostatin analogue TT-232 induces apoptosis in A431 cells:sustained activation of stress-activated kinases and inhibition of signalling to extracellular signal regulated kinases[J].Cell Signal,2001,13(2)∶717-725
  • 5Dalm VA,van Hagen PM,van Koetsveld PM,et al.Cortistatin rather than somatostatin as a potential endogenous ligand for somatostatin receptors in the human immune system[J].J Clin Endocrinol Metab,2003,88(16)∶270-276.
  • 6Kulke MH,Mayer RJ.Carcinoid tumors[J].New Engl J Med,1999,340(5):858-68.
  • 7Ganim RB,Noton JA.Recent advances in carcinoid pathogenesis,diagnosis and management[J].Surg Oncol,2000,9(6):173-179.
  • 8Tang C,Wang C,Tang L.Effects of combined octreotide and aspirin on the growth of gastric cancer[J].Chin Med J (Engl),2003,116(4):373-377.
  • 9Reubi JC,Zimmerman A,Jonas S,et al:Regulatory peptide receptors in human hepatocelluar carcinomas[J].Gut,1999,45(6):766-774.
  • 10Samonakis DN,Joanna M,Theodora A,et al.Treatment of hepatocellular carcinoma with long acting somatostatin analogues[J].Oncology Rep,2002,9(4):903-907.

二级参考文献53

  • 1[1]Bajetta E,Carnaghi C,Ferrari L.The role of somatostat in analogues in the treatment of gastroenteropancreatic endocrine tumors[J].Digestion,1996; 57 Suppl1:72.
  • 2[2]Radulovic S,Schally AV,Reile H.Inhibitory effects of antagonists o f bombesin/gastrin releasing peptide (GRP) and somatostatin analog(RC-160) on g rowth of HT-29 human colon cancers in nude mice[J].ActaOncol,1994;33(6):693.
  • 3[3]Cascinu S,Del-Ferro E,Catalano G.A randomised trial of octreotide vs best supportive care only in advanced gastrointestinal cancer patients refrac tory to chemotherapy[J].Br JCancer,1995;71(1):97.
  • 4[4]Buscail L, Delesque N, Esteve JP. Stimulation of tyrosinephosph atase and inhibition of cell proliferation by somatostatin analogues:Mediation b y human somatostatin receptor subtypes SSTR1 andSSTR2[J].Proc Natl Acad Sci USA,1994;81:2315.
  • 5[5]Reubi JC,Heitz PU,Landolt AM.Hormone producing gastrointestinal t umors contain a high density of somatostatin receptors[J].J Clin Endocrinol Metal,1987;65:65.
  • 6[6]Boige M,Dupont C,Chenut B.Beta-adrenergic regulation of cyclicade nosine 3′,5′monophosphate accumulation in human gastric epitelial glands[J]. Eur J ClinInvest,1984;14:42.
  • 7[7]Park J,Chiba T,Yamada T.Mechanisms for direct inhibition of canine gastric parietal cells by somatostatin[J].J BiolChem,1987;262:14190.
  • 8[8]Vantus T.Csermely P.Teplan I.The tumor-selective somatostatin ana log,TT2～32 induces a biphasic activation of phosphotyrosinephosphatase activity in human colon tumor cell line,SW620[J].TumorBiol,1995;16(4):261.
  • 9Frizelle F A. Octreotide inhibits the growth and development of three types of experimental liver metasta-sis [ J ]. Br J Surg, 1995, 82: 1577.
  • 10Nakaizumi A, Uehara H, Bara M, et al. Inhibition by somatosratin of hepatocarinogene-sis induced by N-nitrosmaorpholine in Sprague-Dawley rats[J ]. Carcino-genesis, 1993,14: 2601.

共引文献54

同被引文献8

引证文献1

二级引证文献1

中国新药杂志
2004年 第5期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部