摘要
①目的 探讨肿瘤坏死因子 -α(TNF -α)在颅脑损伤继发神经源性肺水肿 (NPE)中的作用。②方法 采用Marmarous漫性颅脑损伤模型致大鼠重度弥漫性颅脑损伤 ,测定伤后不同时相血浆中TNF -α的含量及肺组织形态学变化。③结果 伤后 1、3、6小时肺泡间隔逐渐增宽 ,并有以中性白细胞为主的细胞浸润 ,2 4～ 48小时可见部分肺泡出血、水肿 ,肺泡腔内可见大量嗜伊红性蛋白渗出物 ;伤后 1小时血浆中TNF -α升高 ,在伤后 6小时较对照组有非常显著地升高 (P <0 .0 1 )。④结论 TNF
Objective To study the role of tumor necrosis facter α(TNF-α) in neurogenetic pulmonary edema. Methods The levels of TNF-α in plasma were measured in rats which suffered from diffuse brain injury at different time on marmarous model .Results Pulmonary interstitial tissue was increasingly broadened and leucocyte infiltration dominated by neutrophils in 1 h , 3 h and 6 h . From 24 h to 48 h , bleeding ,swelling and protein effusion in pulmonary alveoli were observed ; The levels of TNF-α in plasma in 1 h of brain injury group was higher than in the controls (P<0.05) ; TNF-α in 6 h reached top that is significantly elevated comparing with the controls (P<0.01). Conclusions The inflammatory injury caused by TNF-α is one of the most important machanisms of neurogenetic pulmonary edema .
出处
《华北煤炭医学院学报》
2004年第4期421-422,共2页
Journal of North China Coal Medical College
关键词
肿瘤坏死因子-Α
神经性肺水肿
大鼠
Tumor neerosis factor-α
Neurogeneetic pulmonary edema
Rat
