摘要
【目的】 探讨慢性心力衰竭患者血清瘦素水平改变及其与胰岛素抵抗?胰岛素水平之间的关系? 【方法】 观察60例慢性心力衰竭患者及30例正常对照组血清瘦素水平变化,分析血清瘦素与胰岛素抵抗(以I-AI表示)?胰岛素水平之间的关系? 【结果】 慢性心力衰竭组血清瘦素水平较正常对照组明显升高(12.0±3.4)ng/mL vs (6.3±2.0) ng/mL, P < 0.01?与对照组相比,慢性心力衰竭组胰岛素浓度升高(24.1±5.5) ×10-3 U/L vs (13.9±3.1) ×10-3U/L, P < 0.01,有更高的IAI(4.7±0.6) vs (4.1±0.8), P < 0.01?血清瘦素与胰岛素水平及胰岛素抵抗程度(IAI)显著正相关(r=0.832, P < 0.01; r=0.755, P < 0.01)? 【结论】 慢性心力衰竭患者血清瘦素水平较正常对照组升高?慢性心力衰竭患者存在高胰岛素血症和胰岛素抵抗?血清瘦素与血胰岛素浓度和IAI呈正相关,提示胰岛素-瘦素内分泌轴可能与慢性心衰的高能量消耗状态有关?
Objective To explore the changes of serum leptin level in patients with chronic heart failure (CHF) and the relationship between leptin and insulin resistance and hyperinsulinemia. Methods We studied leptin levels in 60 patients with CHF and 30 normal controls. The relation-ships between serum leptin level and insulin resistance and insulin concertration were also analyzed. Results Compared with the control group, CHF group had significantly increased serum leptin level(12.0±3.4)ng/mL vs (6.3±2.0) ng/mL, P < 0.01, higher fasting insulin levels (24.1±5.5) mU/L vs (13.9±3.1) mU/L, P < 0.01, and higher degree of insulin resistance (indicated by I-AI, 4.7±0.6 vs 4.1±0.8, P < 0.01). Serum leptin level correlated with fasting insulin and IAI (r=0.832, P < 0.01; r=0.755, P < 0.01 respectively). Conclusions Serum leptin levels are increased in patients with CHF. There are positive relationship between serum leptin and insulin concentration and insulin resistance, indicating a possible role of insulin-leptin axis in the increased energy expenditure observed in patients with CHF.
出处
《中山大学学报（医学科学版）》
CAS
CSCD
北大核心
2004年第3期253-255,共3页
Journal of Sun Yat-Sen University:Medical Sciences
基金
教育部原中山医科大学博士课题基金资助项目(01035)
