摘要
目的 :研究激活蛋白 2 (AP 2 )在非小细胞肺癌 (NSCLC)中的表达及其与肿瘤生物学特征的关系。方法 :采用免疫组织化学法 (ABC法 )对 5 0例NSCLC和 1 5例远离肿瘤的正常肺组织中AP 2蛋白的表达状况进行检测 ,分析其在NSCLC和正常肺组织中表达以及与病理分级、组织学类型、淋巴结转移及临床分期的关系。结果 :①AP 2在正常肺组织无表达 ,在NSCLC组织表达阳性率为 32 % ,较正常对照明显增高 (P <0 .0 5 ) ;②AP 2表达增高与NSCLC的病理分级和临床分期相关。病理分级Ⅲ级者AP 2表达阳性率 (5 7.89% )高于病理分级Ⅰ～Ⅱ者(1 6 .1 3% ) (P <0 .0 5 )。临床Ⅲ～Ⅳ期表达阳性率 (4 4 .83% )高于临床Ⅰ～Ⅱ期者 (1 4 .2 9% ) (P <0 .0 1 ) ;有淋巴结转移组AP 2表达阳性率 (4 0 .5 4 % )高于无淋巴结转移组 (7.7% ) (P <0 .0 5 )。结论 :正常肺组织AP 2表达阴性 ,NSCLC癌组织AP 2表达阳性率明显高于正常肺组织。AP 2表达水平与NSCLC临床分期、病理分级、淋巴结转移有关 ,提示AP
Objective To determine the active protein 2 (AP 2) expression in non small cell lung cancer (NSCLC) and the relationship between the expression and tumor biological characteristics. Methods Fifty NSCLC tissues and 15 normal lung tissues were used to detect the expression of AP 2 transcription factor with the immunohistochemical method. Results The positive rate of AP 2 expression was zero in the normal lung tissues, but 32% in the NSCLC tissues. The AP 2 expression in the NSCLC tissues was significantly elevated (P< 0.05 ).The postive rate of AP 2 expression was significantly higher in the NSCLC tissues of pathological grade Ⅲ (57.89%) than in those of gradeⅠ～Ⅱ(16.13%) (P< 0.05 ), and higher in patients of clinical stage Ⅲ～Ⅳ (44.83%) than in those of stage Ⅰ～Ⅱ( 14.29% ) (P <0.01), and in the NSCLC patients with lymph node metastasis (40.54%) than in those without ( 7.7% ) ( P <0.05).Conclusion The up regulation of AP 2 expression in the NSCLC tissues suggests that AP 2 may be involved in the NSCLC carcinogenesis.AP 2 may play an important role in the genesis and development of NSCLC.
出处
《中南大学学报（医学版）》
CAS
CSCD
北大核心
2004年第2期195-197,共3页
Journal of Central South University ：Medical Science
基金
湖南省科委社会发展基金资助项目 (0 2SS30 73)
