摘要
[目的 ]探讨hMLH1蛋白作为胃癌预警标记物的可能性。 [方法 ]免疫组织化学SP法半定量检测 2 4例非肿瘤患者胃黏膜上皮、39例胃癌患者癌旁黏膜上皮及癌细胞hMLH1蛋白的表达情况 ,比较该蛋白在不同黏膜上皮组织中表达的差异性。 [结果 ]hMLH1蛋白表达率在非肿瘤患者胃黏膜上皮为 33% ,明显低于胃癌患者癌旁黏膜上皮的 72 % (P =0 .0 0 3)及癌细胞的 74 % (P =0 .0 0 1 ) ,但在癌旁黏膜上皮与癌细胞间无显著性差异 (P =0 .799)。 [结论 ]hMLH1蛋白在胃癌患者癌旁黏膜上皮及癌细胞的表达强于非肿瘤患者胃黏膜上皮表达的现象 。
Objective] To identify the possibility of hMLH1 protein as a marker to predict the potentiality of gastric carcinoma occurrence. [ Methods] Immunohistochemistry was used to detect the expression of hMLH1 protein in gastric epithelia of cancer cells and the surrounding epithelia from 24 non-tumor patients and from 39 patients with gastric carcinoma. [Results] The positive rates of hMLH1 protein expression were 33%, 74% and 72% in gastric epithelia of non-tumor patients, gastric cancer cells and their surrounding epithelia, respectively. The positive rate in gastric epithelia of non-tumor patients was significantly lower than those in other two groups, while the positive rates in the two groups were not significantly different. [Conclusion] The results indicate that the possibility of hMLH1 protein as a marker may predict the gastric carcinoma occurrence.
出处
《大连医科大学学报》
CAS
2004年第2期88-89,95,共3页
Journal of Dalian Medical University
关键词
胃癌
错配修复基因
免疫组织化学
gastric carcinoma
mismatch repair gene
immunohistochemistry
