摘要
目的 探索建立人工寒潮环境 ;探讨人工寒潮与脑卒中的关系。方法 观测用经改装的冷藏柜及人工气候箱模拟寒潮时所需条件及达标情况 ;分别将复制成功的易卒中型肾血管性高血压大鼠 (RHRSP)及正常大鼠置于人工寒潮环境中 ,观察大鼠的血压波动、脑血管病变及脑卒中的发生情况。结果 冷藏柜与人工气候箱均能模拟寒潮 ,后者除能控制温度外同时能控制相对湿度 ;人工寒潮来临时RHRSP组大鼠血压波动大、自发性脑卒中明显增多 ,与对照组比较有明显差异 (P <0 0 5 )。结论 人工气候箱较冷藏柜能更好模拟寒潮 ,人工模拟寒潮克服了季节限制且一致性好、易重复 ;人工寒潮可以使RHRSP发生脑卒中 ,可较好模拟气温骤降 (自然寒潮 )时的脑卒中 。
Objective To establish artificial cold environment and to investigate the influence of artificial cold stream on the occurrence of stroke. Methods Artificial cold environment was created in adjusted refrigerator and artificial climatic cabinet with certain coefficients respectively. Stroke prone renovascular hypertensive rats(RHRSP) and normal rats were subjected to artificial cold stream after being put into the established refrigerator or artificial climatic cabinet above, and their blood pressure and the incidence of stroke were determined. Results Both the adjusted refrigerator and artificial climatic cabinet simulated natural cold stream, but the latter exelled in the regulation of relative humidity. In RHRSP subjected to artificial cold stream, the fluctuation of blood pressure was larger and the incidence of stroke was higher than the control( P <0 05). Conclusions Artificial cold stream was associated with higher occurrence of stroke. Artificial climatic cabinet simulated cold stream with good coherence and repetition, thus laid foundation for the further study of the mechanism of cold stream induced stroke.
出处
《中国神经精神疾病杂志》
CAS
CSCD
北大核心
2004年第3期198-201,F003,共5页
Chinese Journal of Nervous and Mental Diseases
基金
中山大学 2 11工程基金 (编号 :0 61)
教育部博士点基金(编号 :995 0 )资助
