摘要
目的观察康脑神颗粒治疗急性脑梗死疗效并探讨其作用机理。方法将69例患者随机分为两组,在西医常规治疗基础上,治疗组口服康脑神颗粒,对照组口服益脑复健胶囊,两组疗程均为28d;治疗前后检测血清白介素1β(IL-1β)、白介素8(IL-8)、血清可溶性细胞间粘附分子(sICAM-1)。结果治疗组临床疗效及对神经功能、IL-1β、IL-8、sICAM-1的改善作用均优于对照组。结论抑制炎性细胞因子、粘附分子等的过度产生,可能是康脑神颗粒保护缺血损伤的作用机理之一。
Objective:To explore the effects and the mechanism of Kangnaoshen Granule(康脑神颗粒,KNS)on patients with acute cerebral infarction(ACI).Methods:69 patients were devided randomly into two groups,the treatment group and the controlled group. Patients in the treament group received KNS,while those in the controlled group received Yinaofujian Capsule(益脑复? 耗?,28 days was the course of treatment for both two groups.Before and after treatment,the method of ELISA was used to examin IL-1β、IL-8、SICAM-1 in blood.Consults:Both the total effective rate and the improvement of neurological function of the patients in the treatment group were markly superior to those in the controlled group.After treatment,and all of the indexes of the treatment group were superior to those of the controlled group.Conclusions:Inhibiting the overproduction inflammatory cyokine and cell adhesion molecules may ascrtbe to the protective effects of KNS on brain injury following ACI.
出处
《中国中医急症》
2004年第7期413-414,共2页
Journal of Emergency in Traditional Chinese Medicine
基金
湖南省自然科学基金重点资助课题(No.99JJY1007)
关键词
急性脑梗死
康脑神颗粒
临床观察
Acute cerebral infarction,Kangnaoshen Granule(康脑神颗粒),clinical study
