摘要
核糖体失活蛋白是一类专一修饰核糖体的大亚基rRNA从而抑制蛋白质生物合成的蛋白毒素,可分为Ⅰ-型和Ⅱ-型两种类型。苦瓜中含有多种Ⅰ-型核糖体失活蛋白,如α-苦瓜素、β-苦瓜素和MAP30等,这些蛋白成分具有抗肿瘤、抗病毒和抗艾滋病等功能,因而近年来引起人们广泛的关注。对苦瓜核糖体失活蛋白的研究进展和应用前景进行了综述。
Ribosome-inactivating proteins (RIPs) are a group of protein toxins that inhibit protein synthesis by
cleaving the largest rRNA of ribosomes. RIPs can be classified into two types, Type Ⅰ and type Ⅱ RIP. Several
Type Ⅰ RIPs, including α-Momorharin, β-Momorcharin and MAP30 have been identified in Momordica charantia.
The antitumor, antiviral and anti-AIDS properties of these proteins have aroused wide interest in this area. Progress
in the study of RIPs in bitter gourd and its application are reviewed in this paper.
出处
《细胞生物学杂志》
CSCD
北大核心
2004年第3期247-251,共5页
Chinese Journal of Cell Biology
基金
浙江省科技计划项目(2004C32014)
关键词
苦瓜
核糖体失活蛋白
抗肿瘤
抗病毒
Momordica charantia
ribosome-inactivating proteins
antitumor
antiviral
