摘要
目的 分析短暂脑缺血发作 (TIA)和脑梗死患者血浆血管性血友病因子 (vWF)、组织型纤溶酶原激活剂 (t PA)和组织型纤溶酶原激活物抑制剂 (PAI 1 )的变化 ,探讨其在急性缺血性脑血管病发病中的意义。方法 选择 71例发病 <72h的脑梗死患者、4 4例最近一次脑缺血发作症状 <72h的TIA者和 4 0例健康体检者进行对照分析。每例均行头部MR扫描 ,TIA患者检查颈部血管超声。ELISA法测定vWF、tPA、PAI 1。结果 TIA组和脑梗死组vWF和PAI 1比对照组明显增高 ,t PA明显降低 ,TIA患者t PA和PAI 1水平低于脑梗死组 ,vWF高于脑梗死组。颈动脉超声显示狭窄和斑块的TIA患者vWF高于超声正常的患者 ,t PA低于超声正常的患者。结论 TIA和脑梗死的发病与内皮细胞损伤和凝血纤溶异常有关。
Objective To study the significance of plasma level of vWF,t PA and PAI 1 as possible markers of endothelial dysfunction in patients with transient ischemic attacks (TIA) and acute cerebral infarction (ALI).Methods 71 patients with ACI (ictus<72h),and 44 TIA who had experienced an episode for less than 72h and 40 controls were enrolled in this study,MRI was performed in order to rule out a new ACI in the territory of qualifying event of TIA and to calculate the CI areas in ACI.Duplex ultrasound was used to assess the degree of atherosclerosis of TIA.The factors were examined by ELISA.Results vWF and PAI 1 were significantly higher and t PA were lower in TIA and ACI than in controls,t PA and PAI 1 were lower and vWF were higher in TIA than in ACI.vWF were higher and t PA were lower in TIA whose carotid artery ultrasound showed more stenosis and plaque formation than those with normal ultrasounography.Conclusions TIA and ACI are associated with endothelial damage and hemostatic abnormalities.
出处
《北京医学》
CAS
北大核心
2004年第2期86-89,共4页
Beijing Medical Journal
