摘要
目的 :探讨不稳定性心绞痛 (UA)患者血清肝细胞生长因子 (HGF)水平变化的临床意义。方法 :用酶联免疫吸附法 (ELISA)测定比较不稳定性心绞痛组 (UA组 ,n =5 0 )、稳定性心绞痛组 (SA组 ,n =3 0 )和对照组 (n =3 0 )心绞痛发作 2 4小时内及治疗 2周后血清HGF水平 ,其中UA组又根据冠状动脉 (冠脉 )造影时冠脉对硝酸甘油的反应分为有固定狭窄患者与无固定狭窄患者两部分。结果 :UA组入院 2 4小时内血清HGF水平比对照组和SA组均高 [( 1674 5 4± 14 5 0 0 3 ) pg/ml对 ( 64 8 90±115 2 0 )pg/ml和 ( 72 8 5 3± 2 88 14 ) pg/ml] ,有非常显著差异 (P <0 0 1) ,而且血清HGF水平与UA分型有关 ,UA组无固定狭窄患者血清HGF水平显著低于有固定狭窄患者 [( 848 44± 14 6 49)对 pg/ml( 185 5 88± 15 44 0 7)pg/ml,P <0 0 1]。UA组发病 2周后血清HGF水平由 ( 1674 5 4± 14 5 0 0 3 ) pg/ml下降至 ( 880 71± 2 0 1 75 ) pg/ml(P <0 0 1) ;其中UA组在 3个月内发生冠脉事件的 5例患者 2周后的血清HGF水平平均为 ( 15 46 80± 93 2 12 ) pg/ml,明显高于UA组患者的平均水平 ( 880 71± 2 0 1 75 ) pg/ml(P <0 0 1)。SA组经治疗后血清HGF水平变化不大 (P >0 0 5 )。结论 :UA患者血清HGF动态升高 ;
Objective: To explore the clinical significance of changes of serum hepatocyte growth factor(HGF) level in patients with unstable angina pectoris (UA). Methods: The serum HGF concentration was determined in 50 UA patients,30 patients with stable angina pectoris (SA) and 30 healthy controls by ELISA. Results: The level of serum HGF in patients with UA 1 674.54±1 450.03 pg/ml was not only significantly higher than in the controls 648.90±115.20 pg/ml ( p <0.01) or SA patients 728.53±288.14 pg/ml ( p <0.01),but also related to the UA sub-types . The HGF level in patients with coronary artery spasm 848.44±146.49 pg/ml was lower than in those with coronary artery stenosis 1 855.88±1 544.07 pg/ml ( p <0.01).The serum HGF level in UA patients decreased 2 weeks after treatment to 880.71±201.75 pg/ml ( p <0.01),but still higher than that of SA or control group. Five patients who had coronary events within 3 months maintained a high serum HGF level of 1 546.80±932.12 pg/ml. Conclusion: There were dynamic changes of serum HGF level in patients with UA,and the serum HGF level was responsible for the poor prognosis.HGF level provides a serological mark for the stratification of angina risk.
出处
《中国循环杂志》
CSCD
北大核心
2004年第2期130-132,共3页
Chinese Circulation Journal
基金
20 0 0年上海市医学发展基金重点研究课题资助项目 (2 0 0 0IZD0 0 2 )
