摘要
Salicylic acid as a drug carrying agent was intercalated into microporous poly(ε-caprolactone)(PCL) and PCL resin particles using supercritical CO 2 as solvent. The drug releasing currves in 95% ethanol solution for open-hole PCL and close-hole PCL particles have been obtained and the releasing half-life(t 1/2) for both systems were calculated to be 35 h and 57 h, respectively. The latter appears more preferable.
Salicylic acid as a drug carrying agent was intercalated into microporous poly(ε-caprolactone)(PCL) and PCL resin particles using supercritical CO 2 as solvent. The drug releasing currves in 95% ethanol solution for open-hole PCL and close-hole PCL particles have been obtained and the releasing half-life(t 1/2) for both systems were calculated to be 35 h and 57 h, respectively. The latter appears more preferable.
出处
《应用化学》
CAS
CSCD
北大核心
2004年第7期751-753,共3页
Chinese Journal of Applied Chemistry
关键词
超临界CO2
水杨酸
聚Ε-己内酯
缓释
supercritical CO2,salicylic acid,poly(ε-caprolactone ),drug releasing
