摘要
目的:观察辛伐他汀对高血压病人血压的影响。方法:42例高血压伴高血脂病人作自身前、后对照,在服用氨氯地平控制血压的基础上,加用辛伐他汀调脂治疗12周。观察用药前、后24小时动态血压的变化。结果: 12周后,患者的总胆固醇、低密度脂蛋白胆固醇和甘油三酯水平显著降低,而高密度脂蛋白胆固醇水平升高不显著。在调脂治疗后血压略有降低,但不显著。结论:辛伐他汀调脂疗效确切,对血压有轻度影响。
Objective: To observe the effect of simvastatin on the blood pressure of patients with hypertension and
hypercholesterolemia. Methods: A total of 42 cases were given with simvastatin 20mg, 1/d for 12 weeks after the
blood pressures had been decreased to normal range with Amlodipine, the effect of simvastatin on anti-hypertension
was assessed with ambulatory blood pressure monitoring (ABPM) for 24 h, the change of their blood pressures were
compared with themselves before and after the treatment. Results: After 12 weeks, levels of TC, LDL-C and TG were
significantly decreased, however, the elevation of HDL-C was not significant before and after the treatment. The
change of blood pressures after the treatment was slight and not significant statistically. The adverse reaction of
simvastatin was mild and relatively rare. Conclusion: The simvastatin effected slightly the change of blood pressure
in patients with hypertension and hypercholesterolemia, but not significat (P>0.05).
出处
《心血管康复医学杂志》
CAS
2004年第3期235-237,共3页
Chinese Journal of Cardiovascular Rehabilitation Medicine
