摘要
目的 :探讨短期应用他汀类降脂药普伐他汀对慢性心衰患者心功能的作用。方法 :64例慢性心力衰竭患者 ,随机分为普伐他汀治疗组 ( 3 4例 )和对照组 ( 3 0例 ) ,对照组给予强心、利尿、扩血管治疗 ,治疗组在此基础上加用普伐他汀 ,剂量为 2 0mg ,每晚 1次 ,疗程 8周 ,测定左室射血分数、血清肿瘤坏死因子 -α和白介素 -6及其变化。结果 :普伐他汀治疗组与对照组比较 ,血清胆固醇有适度的下降 ;治疗后两组左室射血分数均有所提高 ,但普伐他汀组明显 ,与对照组比较 ,有统计学差异 ;治疗后与治疗前比较 ,普伐他汀组血清肿瘤坏死因子和白介素 -6的降低比对照组更明显。结论 :短期普伐他汀治疗能改善慢性心衰患者心功能和神经激素的平衡失调状况。
Aim:To study the effect of short-term pravastatin therapy on heart function in patients with chronic heart failure (CHF).Methods:Sixty-four patients with CHF were randomly divided into 2 groups. Patients in control group (n=30) were given inotropic agent, diuretic, and vasodilator therapy. Patients in pravastatin group (n=34) were given pravastatin 20 mg every evening for 8 weeks on the basis of the therapy in control group. The left ventricular ejection fraction and the concentration of tumor necrosis factor alpha (TNF alpha) and inerleukin-6 (IL-6) were measured. Results:After 8 weeks, patients receiving provastatin exhibited a modest reduction in serum cholesterol level compared with control group. LVEF was increased in all patients after therapy but it was increased more apparently in provastatin-treated group than that in control group. The level of TNF-alpha and IL-6 was decreased after provastatin treatment.Conclusion:Short-term pravastatin therapy can improve cardiac function and neurohormonal imbalance.
出处
《上海医药》
CAS
2004年第6期275-276,共2页
Shanghai Medical & Pharmaceutical Journal
