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PSP/Reg蛋白家族在慢性胰腺炎中研究进展

Research Progress of PSP/Reg Protein Family in Chronic Pancreatitis
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摘要 胰石蛋白(pancreatic stone protein, PSP),胰腺炎相关蛋白(pancreatitis-associated protein, PAP)和再生蛋白I (Regenerating protein I, Reg I)先后被独立地发现于胰腺的外分泌和内分泌疾病。随后的研究表明,PSP和RegI是同一种蛋白并且其与PAP属于同一种蛋白家族。PSP/Reg和PAP具有相同的选择性特异性的胰酶切割位点,并被胰酶降解形成不溶性纤维。由于有假说提出PSP具有抑制胰石形成的功能,所以PSP又称为胰石蛋白(lithostathine)。但是胰石蛋白的抑制结石形成的功能受到了质疑。目前大部分研究结果表明PSP对于结石形成具有促进作用,而非抑制。
出处 《临床医学进展》 2018年第7期644-649,共6页 Advances in Clinical Medicine
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