摘要
慢性阻塞性肺疾病(Chronic obstructive pulmonary disease, COPD)是一种持续存在的气流受限,呈进行性发展,伴有气道和肺慢性炎症反应的常见疾病。Notch是一种跨膜蛋白,通过直接的细胞–细胞间接触调节慢性阻塞性肺疾病、肺动脉高压和肺癌的病理生理功能过程。本文就Notch信号与COPD的关系对近来的研究进行综述,重点讨论了Notch信号通路活化参与免疫炎症紊乱、气道上皮–间质转化、肺间质纤维化,促进Klotho甲基化加重肺损伤等可能的COPD新病理机制,为临床治疗COPD提供新思路。
Chronic obstructive pulmonary disease (COPD) is a common disease that is characterized by the progressive, persistent restriction in airflow and chronic inflammation of the respiratory tract and lungs. Notch is a transmembrane protein that regulates the pathophysiological processes of COPD, pulmonary hypertension, and lung cancer through direct cell-cell contact. This mini-review focuses on the illustration of the relationship between the Notch signaling and COPD in terms of the involvement of Notch signaling pathway in immune inflammatory disorders, airway epithelial-interstitial transformation, pulmonary fibrosis and the promotion of Klotho methylation aggravating lung injury, which provides new insights into the pathological mechanisms and clinical treatment of COPD.
出处
《临床医学进展》
2020年第8期1573-1580,共8页
Advances in Clinical Medicine
