摘要
干燥综合征(Sjögren’s syndrome, SS)是一种以外分泌腺受累为主的慢性全身性自身免疫性疾病,即唾液腺和泪腺存在淋巴细胞性和浆细胞性浸润,并伴有自身抗体的产生,其典型的临床表现为持续性的口干和眼干。自身免疫性甲状腺疾病(autoimmune thyroid diseases, AITD)是最常见的器官特异性自身免疫性疾病,主要包括弥漫性毒性甲状腺肿(Graves’ disease, GD)、原发性甲状腺功能减退症(简称甲减)和自身免疫性甲状腺炎(autoimmune thyroiditis, AIT)。临床上,SS和AITD经常共存于同一患者中,从而导致复杂的多自身免疫,这是自身免疫性疾病患者异质性表达的一个特殊例子。本文描述了近30年国内外文献中SS合并AITD的发病率,总结了SS合并AITD的发病机制和病因以了解这种令人着迷的自身免疫关联。
Sjögren’s syndrome (SS) is a chronic systemic autoimmune disease dominated by exocrine gland involvement. SS is characterized by lymphocytic and plasma cell infiltration of salivary and lacrimal glands accompanied by the production of autoantibodies, and its typical clinical manifestations are persistent dry mouth and dry eyes. Autoimmune thyroid diseases (AITD) are the most common organ-specific autoimmune diseases, including Graves’ disease (GD), primary hypothyroidism and autoimmune thyroiditis (AIT). Clinically, SS and AITD often coexist in the same patient, resulting in complex polyautoimmunity, which is a special case of heterogeneous expression in patients with autoimmune diseases. This review describes the incidence of AITD in SS in the last 30 years of domestic and foreign literature, and summarizes the pathogenesis and etiology of AITD in SS to explore this fascinating autoimmune association.
出处
《临床医学进展》
2022年第3期2266-2273,共8页
Advances in Clinical Medicine
