摘要
心血管疾病导致的发病和死亡风险显著增加,对人类生命健康造成重要影响。心血管疾病发生日益年轻化,人们对相关生物标记物对于心血管疾病的识别越来越感兴趣。生物标志物可分为四种类型:诊断性生物标志物促进疾病的早期诊断、预后生物标志物估计疾病进程、预测性生物标志物用于预测治疗的反应、治疗性生物标志物发现靶点。当前生物标志物除了传统的单指标对于心血管危险预测之外,某些多指标组合可能对于疾病的预测也被广泛提及,在改善心血管疾病风险预测方面显示出巨大潜力。进一步的研究需要评估生物标志物的有效性,以及将生物标志物纳入临床实践的策略是否有助于优化决策和治疗管理。
Cardiovascular diseases significantly increase the risk of morbidity and mortality, which has a significant impact on human life and health. The incidence of cardiovascular disease is becoming younger and younger, and people are more and more interested in the identification of cardiovascular disease with related biomarkers. Biomarkers can be divided into four types: diagnostic biomarkers promote early diagnosis of disease, prognostic biomarkers estimate disease progression, predictive biomarkers are used to predict response to treatment, and therapeutic biomarkers discover targets. In addition to the traditional single-indicator prediction of cardiovascular risk, some combinations of multi-indicator predictors of disease have also been widely mentioned, which shows great potential in improving the prediction of cardiovascular disease risk. Further research is needed to assess the effectiveness of biomarkers and whether strategies to incorporate biomarkers into clinical practice can help optimize decision making and treatment management.
出处
《临床医学进展》
2022年第4期2898-2903,共6页
Advances in Clinical Medicine
