摘要
帕金森病是常见的神经退行性疾病,表现为静止性震颤、运动迟缓、肌强直、姿势平衡障碍、嗅觉功能障碍、睡眠障碍、自主神经功能障碍、精神障碍、认知障碍、疼痛和疲劳等临床症状。在疾病的早期与其他神经退行性有许多类似的临床症状,使帕金森病的早期诊断相对困难。影像学及核医学的发展,通过量化体内代谢物成分、探测组织微观结构、检测敏感性指标等影像学检查及显示分子在机体内分布情况的核医学显像技术,提高了帕金森病的早期诊断。文中重点阐述了质子磁共振波谱、磁共振弥散张量成像、磁敏感加权成像及多巴胺转运蛋白正电子发射断层扫描显像在诊断早期帕金森病中的研究进展。
Parkinson’s disease is a common neurodegenerative disease. it is characterized by clinical symp-toms such as resting tremor, motor retardation, myotonia, postural balance disorder, olfactory dysfunction, sleep disorder, autonomic nervous dysfunction, mental disorder, cognitive impairment, pain and fatigue. There are many clinical symptoms similar to other neurodegenerative diseases in the early stage of the disease, which makes the early diagnosis of Parkinson’s disease relatively difficult. With the development of imaging and nuclear medicine, the early diagnosis of Parkinson’s disease has been improved by quantifying the composition of metabolites, detecting tissue microstructure, detecting sensitivity indexes and nuclear medical imaging technology to show the distribution of molecules in the body. This paper focuses on the research progress of proton magnetic resonance spectroscopy, magnetic resonance diffusion tensor imaging, magnetic sensitivity weighted imaging and dopamine transporter positron emission tomography in the di-agnosis of early Parkinson’s disease.
出处
《临床医学进展》
2022年第12期11946-11953,共8页
Advances in Clinical Medicine
