摘要
血清类黏蛋白1样蛋白3 (Orosomucoid 1-like protein 3, ORMDL3)是ORM家族蛋白的一种,ORM家族存在3中同源蛋白——ORMDL1、ORMDL2、ORMDL3。ORMDL3作为锚定在内质网中的跨膜蛋白,具有调节钙离子稳态、调控未折叠蛋白反应与内质网应激的作用。ORMDL3在全基因组关联研究中被确定为哮喘相关蛋白与肥胖相关蛋白,存在调控细胞铁死亡、自噬、凋亡作用。目前ORMDL3的相关研究表明其存在调节鞘脂代谢的功能,在肥胖条件下对呼吸功能产生一定的影响。本文对ORMDL3在肥胖条件下对呼吸系统的影响及机制进行探讨。
Orosomucoid 1-like protein 3 (ORMDL3) is one of the ORM family proteins, and there are three ho-mologous proteins in the ORM family—ORMDL1, ORMDL2, and ORMDL3. As a transmembrane pro-tein anchored in the endoplasmic reticulum, ORMDL3 has the functions of regulating calcium ion homeostasis, regulating unfolded protein response and endoplasmic reticulum stress. ORMDL3 is identified as an asthma-associated protein and an obesity-associated protein in genome-wide asso-ciation studies, and plays a role in regulating cell ferroptosis, autophagy, and apoptosis. Current re-search has shown that ORMDL3 also has the function of regulating sphingolipid metabolism, and ef-fects on respiratory function under obese conditions. Here we discuss the influence and mecha-nisms of ORMDL3 on the respiratory system under obesity.
出处
《临床医学进展》
2023年第6期10136-10141,共6页
Advances in Clinical Medicine
