摘要
类风湿关节炎是慢性自身免疫学疾病,可侵蚀多关节,因多脏器受累、致畸,故早期合理化治疗至关重要,其发生基础为免疫损害,抗体可帮助早期诊断。抗突变型瓜氨酸波形蛋白抗体(Anti-Mutated Citrullinated Vimentin, MCV)属于抗瓜氨酸化蛋白抗体家族,在诊断类风湿性关节炎中的灵敏度和特异度与抗环状瓜氨酸抗体类似,同时抗MCV抗体阳性亦可预测关节破坏程度,可用于早期诊断及预后评估。本文就抗MCV抗体在类风湿性关节炎中的相关研究作一综述。
Rheumatoid arthritis is a chronic autoimmunological disease that can erode multiple joints. Due to the involvement of multiple organs and teratogenesis, early rational treatment is crucial. Its occur-rence is based on immune damage and antibodies can help early diagnosis. Anti-mutated citrulli-nated vimentin (MCV) belongs to the anti-citrullinated protein antibody family, and its sensitivity and specificity in the diagnosis of rheumatoid arthritis are similar to that of anti-cyclic citrullinated antibodies. Meanwhile, positive anti-MCV antibodies can also predict the degree of joint destruction, and can be used for early diagnosis and prognosis assessment. This article reviews the research progress of anti-MCV antibody in rheumatoid arthritis.
出处
《临床医学进展》
2023年第12期20305-20310,共6页
Advances in Clinical Medicine
