摘要
转运RNA (transfer RNA, tRNA)衍生的RNA片段(transfer RNA-derived fragments, tRFs)是一种新型的小非编码RNA (non-coding RNA, ncRNA)。tRFs广泛表达于生物体的各种细胞内。研究发现tRFs可以通过调控翻译、基因表达和细胞周期对肿瘤的发生发展产生非常重要的作用,其在功能上与微小RNA (microRNA, miRNA)具有相似之处,但其具体机制尚不完全清楚,还需进一步探究。本文对tRFs的分类、生物学功能、其异常表达对不同肿瘤的影响以及在肿瘤新型诊断生物标记物和潜在治疗靶点的研究进行了综述,以期为未来的研究提供一个可能的研究思路和方向。
RNA fragments (tRFs) derived from transporting RNA (tRNA) is a new type of small non-coding RNA (ncRNA). tRFs is widely expressed in various cells of organisms. Studies have found that tRFs can play a very important role in tumor occurrence and development by regulating translation, gene expression and cell cycle. It is functionally similar to micro-RNA (miRNA), but its specific mechanism is not completely clear and needs to be further explored. This article reviews the clas-sification and biological function of tRFs, the effect of its abnormal expression on different tumors, as well as the research on new diagnostic biomarkers and potential therapeutic targets of tumors, in order to provide a possible research idea and direction for future research.
出处
《临床医学进展》
2024年第2期4213-4220,共8页
Advances in Clinical Medicine
