摘要
抗磷脂抗体综合征(Antiphospholipid syndrome, APS)是一种实验室检查以抗磷脂抗体(antiphospholipid antibody, APL)持续阳性,临床标准以病态妊娠、血栓形成为主要特征的非炎性自身免疫性疾病。近年来,随着对APS的逐渐研究及认识的增加,临床上产科抗磷脂抗体综合征的患者越来越多见,APS孕妇的围产期的不良妊娠结局发生率也越来越高,早期且全程合理应用药物治疗可以有效改善妊娠结局及胎儿结局,所以APS患者的妊娠管理问题一直是风湿科和产科的难点和重点。由此可见,产科APS及其相关临床观察及母婴预后相关研究是临床研究者探讨的热点,下文就对目前研究进行详细阐述。
Antiphospholipid syndrome (APS) is a noninflammatory autoimmune disorder characterized by persistently positive laboratory tests of antiphospholipid antibody (APL) and characterized by pathological pregnancy and thrombosis. In recent years, with the gradual research and increasing understanding of APS, there are more and more patients with obstetric antiphospholipid syndrome in clinical practice, and the incidence of adverse pregnancy outcomes in the perinatal period of APS pregnant women is also increasing. Rational application of drug therapy in the early and whole process can effectively improve pregnancy outcomes and fetal outcomes. Therefore, the pregnancy management of APS patients has always been the difficulty and focus of rheumatology and obstet-rics. It can be seen that obstetric APS and its related clinical observations and maternal and infant prognostic studies are hot topics discussed by clinical researchers. The current studies are elabo-rated in the following paragraphs.
出处
《临床医学进展》
2024年第3期234-240,共7页
Advances in Clinical Medicine
