摘要
原发性醛固酮增多症作为继发性高血压的重要诱因之一,其醛固酮腺瘤亚型尤为引人关注。鉴于手术为该病症的首选治疗方式,除了对血压的显著影响外,醛固酮过量对心血管系统的实质性损害以及代谢的紊乱亦不容忽视。近年来,KCNJ5基因突变被确认为醛固酮腺瘤的主要遗传特征,尽管其人群特征已受到多方研究,但关于该突变对心血管及代谢方面的临床影响仍显不足。因此,本文致力于综述和分析相关文献,全面探讨KCNJ5基因突变在醛固酮腺瘤患者中的普遍特点,以及其与心脏、血管和代谢之间的关系。此外,我们也对目前研究的不足之处和未来需要深入探讨的问题进行了思考和展望。通过这一系统性的论述,期望为醛固酮腺瘤中KCNJ5基因突变导致的心血管损害和代谢并发症的临床研究提供新的视角。
Primary aldosteronism, a significant contributor to secondary hypertension, particularly draws attention in aldosterone adenoma. Considering surgery as the preferred treatment for this condition, apart from its notable impact on blood pressure, the substantial damage to the cardiovascular system and disruptions in metabolism caused by excessive aldosterone cannot be overlooked. In recent years, mutations in the KCNJ5 gene have been identified as a major genetic characteristic of aldosterone adenomas. Despite extensive research on the population characteristics associated with this mutation, there remains insufficient understanding of its clinical implications on the cardiovascular and metabolic aspects. Therefore, this paper aims to comprehensively review and analyze relevant literature, delving into the common features of KCNJ5 gene mutations in aldosterone adenoma patients, as well as their relationships with the heart, blood vessels, and metabolism. Additionally, we contemplate and prospect on the shortcomings in current research and the issues that require further exploration. Through this systematic review, we hope to provide a new perspective for clinical research on the cardiovascular damage and metabolic complications resulting from KCNJ5 gene mutations in aldosterone adenomas.
出处
《临床医学进展》
2024年第3期2135-2142,共8页
Advances in Clinical Medicine
