摘要
自噬,作为一种生理过程,参与了肿瘤的发生发展。一方面,它能清除受损细胞器,抑制炎症,从而延缓肿瘤的发生;另一方面,它又能促进细胞的稳态,增强肿瘤的适应性,从而促进肿瘤的进展。髓母细胞瘤,作为儿童常见的恶性肿瘤之一,因其独特的解剖位置、细胞起源和临床表现,成为了导致儿童死亡的重要原因之一。目前研究发现,自噬在不同亚型的髓母细胞瘤中的作用存在差异,并影响疾病的进展。因此,本综述以髓母细胞瘤的分子亚型为出发点,深入探讨了自噬在髓母细胞瘤不同分子亚型中的作用机制,为髓母细胞瘤的治疗找到新的潜在治疗靶点,为患者探索出新的治疗方向。
Autophagy, as a physiological process, plays a role in the initiation and progression of tumors. On one hand, it can clear damaged organelles and suppress inflammation, thereby slowing down tumor development;on the other hand, it can promote cellular homeostasis, enhancing the adaptability of tumors and facilitating their progression. Medulloblastoma, as one of the common malignant tumors in children, has become a significant contributor to childhood mortality due to its unique anatomical location, cell origin, and clinical manifestations. Current research indicates that the role of autophagy varies among different subtypes of medulloblastoma, influencing the course of the disease. Therefore, this review, starting from the molecular subtypes of medulloblastoma, delves into the mechanisms of autophagy in different molecular subtypes, aiming to identify new potential therapeutic targets for medulloblastoma treatment and explore novel therapeutic directions for patients.
出处
《临床医学进展》
2024年第3期2247-2253,共7页
Advances in Clinical Medicine
