摘要
随着医学研究的深入,转录因子作为一种重要的细胞内调节蛋白,在肿瘤生成与发展中的作用越来越受到关注。本综述基于前期工作18篇文章,涵盖肿瘤标志物与预后分析、细胞功能、蛋白质相互作用与细胞生物学以及基因表达与调控机制四个方面,系统地总结了转录因子在肿瘤进展中的研究现状及其作用机制。其中,ERCC1与非小细胞肺癌关系的研究强调了其在肺鳞癌预后上的潜在标志物角色。信号通路方面的研究揭示了转录因子在细胞增殖、分化及肿瘤进程中的重要作用。对TRIB2、TDP-43及其他分子的研究揭示了它们之间的相互作用,可能影响肿瘤细胞的幸存与增殖。同时,抑癌基因PDCD5、lncRNAs等在基因表达调控中起到关键调节作用,为理解肿瘤生成的分子机制提供了新的视角。本综述从分子角度为开发新的癌症治疗靶点提供了可能的方向,为临床治疗提供了理论基础。
With the deepening of medical research, the role of transcription factors as an important intracellular regulatory protein in tumor generation and development has attracted increasing attention. Based on 18 articles from previous work, covering four aspects: tumor markers and prognosis analysis, signaling pathway and cell function, protein interaction and cell biology, and gene expression and regulation mechanism, this review systematically summarizes the research status and action mechanism of transcription factors in tumor progression. Among them, the relationship of ERCC1 with non-small cell lung cancer highlights its potential marker role in the prognosis of lung squamous cell carcinoma. Studies on signaling pathways have revealed the important roles of JNK pathway and Wnt/β-catenin pathway in cell proliferation, differentiation and tumor progression. Studies of TRIB2, TDP-43, and other molecules have revealed the interactions between them that may affect the survival and proliferation of tumor cells. Meanwhile, the tumor suppressor genes PDCD5 and lncRNAs play key regulatory roles in the regulation of gene expression, providing a new perspective for understanding the molecular mechanism of tumor generation. This review provides possible directions for developing new targets for cancer therapy from a molecular perspective and provides a theoretical basis for clinical treatment.
出处
《临床医学进展》
2024年第5期980-989,共10页
Advances in Clinical Medicine
