摘要
目的:系统评价糖尿病患者同型半胱氨酸(Hcy)和尿酸(UA)的相关性。方法:采用计算机检索CNKI、CBM、WangFang、PubMed、Embase、Web of science、Cochrane Library数据库,查找糖尿病患者Hcy与UA相关性的研究,检索时间为建库至2024年2月,应用Stata 17.0软件对纳入的研究进行Meta分析。结果:20项研究纳入本荟萃分析。在整体糖尿病人群中,Hcy与UA的相关性有统计学意义[ES = 0.54, 95% CI (0.39, 0.69), P < 0.001];在单纯糖尿病亚组分析中,Hcy与UA的相关性有统计学意义[ES = 0.24, 95% CI (0.2, 0.29), P < 0.001];在糖尿病肾病亚组中,Hcy与UA的相关性有统计学意义[ES = 0.59, 95% CI (0.31, 0.88), P < 0.001];在糖尿病合并高血压亚组分析中,Hcy与UA的相关性有统计学意义[ES = 0.99, 95% CI (0.80, 1.18), P < 0.001];在糖尿病合并高尿酸(HUA)的亚组分析中,Hcy与UA的相关性有统计学意义[ES = 0.71, 95% CI (0.28, 1.14), P < 0.001]。结论:在糖尿病合并高血压和HUA的患者中,Hcy与UA的相关性更强,在单纯糖尿病和糖尿病肾病患者中,Hcy与UA的相关性弱一些。积极控制Hcy和UA的水平对于糖尿病患者预后有着重要的影响。
Objective: To systematically evaluate the correlation between homocysteine (Hcy) and uric acid (UA) in patients with diabetes mellitus. Methods: CNKI, CBM, WangFang, PubMed, Embase, Web of science, and Cochrane Library databases were searched for studies on the association between Hcy and UA in diabetic patients from inception to February 2024, and Stata 17.0 software was used for meta-analysis of the included studies. Results: Twenty studies were included in this meta-analysis. The association between Hcy and UA was statistically significant in the overall diabetic population [ES = 0.54, 95% CI (0.39, 0.69), P < 0.001];in the subgroup analysis of diabetes alone, the association between Hcy and UA was statistically significant [ES = 0.24, 95% CI (0.2, 0.29), P < 0.001];in the diabetic nephropathy subgroup, the association between Hcy and UA was statistically significant [ES = 0.59, 95% CI (0.31, 0.88), P < 0.001];the correlation between Hcy and UA was statistically significant in the subgroup analysis of diabetes mellitus and hypertension [ES = 0.99, 95% CI (0.80, 1.18), P < 0.001], and in the subgroup analysis of diabetes mellitus with high uric acid (HUA), the correlation between Hcy and UA was statistically significant [ES = 0.71, 95% CI (0.28, 1.14), P < 0.001]. The association between Hcy and UA was stronger in patients with diabetes mellitus and hypertension and HUA, and weaker in patients with diabetes mellitus alone and diabetic nephropathy. Active control of UA and Hcy levels has an important impact on the prognosis of diabetic patients. Conclusion: The association between Hcy and UA was stronger in patients with diabetes mellitus and hypertension and HUA, and weaker in patients with diabetes mellitus alone and diabetic nephropathy. Active control of UA and Hcy levels has an important impact on the prognosis of diabetic patients.
出处
《临床医学进展》
2024年第7期996-1006,共11页
Advances in Clinical Medicine
