摘要
本文采用兔子心脏的窦房结–心房组织完整的二维细胞解剖模型,通过计算机仿真模拟研究了酸碱平衡失调对细胞膜电压形成及传导过程的影响。模拟结果显示,一方面,可以观测到,当机体呈现一定程度的酸中毒或碱中毒时,窦房结起搏活动发生阻滞,这与临床上酸碱平衡失调引起心血管系统的功能障碍相吻合;另一方面,可以通过引入适当的外界低频信号刺激来消除这种死振,从而让窦房结组织重新恢复正常搏动功能。上述结果将有助于揭示酸碱平衡失调对复杂的心脏体系内在机能的影响,对人类心血管疾病的临床诊断与治疗有一定的理论指导作用。
In this paper, by using a 2D anatomical model of the intact SA node and surrounding atrial muscle of the rabbit heart, the effect of the acid-base balance disturbance on the formation of cell membrane voltage and its conductive process is investigated by computer simulation. The results show, on one hand, once the body showed acidosis or alkalosis and to a certain level, it can be found, the pacemaking active block of sinoatrial node-atrium appears, which indicates the acid-base balance disturbance can cause dysfunction of the cardiovascular system just like the clinical mentioned;On the other hand, we found this oscillation death could be eliminated by introducing the appropriate exter- nal low frequency signal stimulation, thereby the normal pacemaking activity could be restored in the SA node tissue. These results may contribute to the understanding about the effect of acid-base balance disturbance on the complex car- diac system, and provide a theoretical guidance on the clinical diagnosis of cardiovascular diseases.
出处
《计算生物学》
2013年第1期1-6,共6页
Hans Journal of Computational Biology
基金
国家自然科研基金理论物理专款项目(114047017)
安徽省自然科研基金(2009KJ099B)
威康信托基金Wellcome Trust (Grant No.081808/Z/ 06/Z)
英国生物工艺生物科学研究基金BBSRC(Grant No. BBS/B1678X),UK。
