摘要
动脉粥样硬化(Atherosclerosis, As)是一种慢性炎症性疾病,好发于血管分支、分叉及弯曲内侧这些血流紊乱部位。局部因素如血流动力学在动脉粥样硬化好发局部位置过程中起重要作用。内皮细胞表面有很多可以感受力刺激的机械敏感受体,机械敏感受体一旦活化会激活细胞内数条信号通路,引起某些转运因子发生磷酸化,与机械敏感响应原件结合调控机械敏感基因的表达,调节细胞功能变化。本文就机械敏感受体PECAM-1在机械信号转导中的作用进行综述。
Atherosclerosis is a chronic, inflammatory disease form at specific regions of the arterial tree such as in the vicinity of branch points, the outer wall of bifurcations, and the inner wall of curvatures, where disturbed flow occurs. Local factors, such as hemodynamic forces, play a major role in the re-gional localization of atherosclerosis. Endothelial cell (EC) surfaces are equipped with numerous mechanoreceptors capable of detecting and responding to forces stimuli. After activation of mecha-noreceptors, a complex network of several intracellular pathways is triggered. These pathways lead to phosphorylation of several transcription factors (TFs), which bind positive or negative shear stress responsive elements (SSREs) at promoters of mechanosensitive genes, ultimately, modulat-ing cellular function and morphology. Here, we focus on the function of platelet endothelial cell ad-hesion molecule-1 (PECAM-1), one of the mechanoreceptors, in mechanotransduction.
出处
《药物资讯》
2018年第2期21-26,共6页
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