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Aminated Cyclopropylmethylphosphonates as Potent Prostate Cancer Inhibitors

Aminated Cyclopropylmethylphosphonates as Potent Prostate Cancer Inhibitors
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摘要 Inspired by the anti-pancreatic promising results of our novel aminated cyclopropylmethylphosphonate compounds, an in vitro anti-prostate cancer activity exploration of these compounds was carried out on human prostate cancer cell line PC-3, and showed potent inhibiting activity at low micromolar concentrations (with an IC50 of approximately 45 μM). Inspired by the anti-pancreatic promising results of our novel aminated cyclopropylmethylphosphonate compounds, an in vitro anti-prostate cancer activity exploration of these compounds was carried out on human prostate cancer cell line PC-3, and showed potent inhibiting activity at low micromolar concentrations (with an IC50 of approximately 45 μM).
作者 Abed Al Aziz Al Quntar Ibrahim Abasy Abed Al Aziz Al Quntar;Ibrahim Abasy(Department of Chemistry and Chemical Technology, Faculty of Science and Technology, Al-Quds University, Jerusalem, Palestine;Department of Microbiology and Immunology, Al-Quds University, Jerusalem, Palestine)
出处 《Journal of Biosciences and Medicines》 2024年第7期239-244,共6页 生物科学与医学(英文)
关键词 Prostate Cancer Cancer Cyclopropylphophonates AMINOPHOSPHONATES CYCLOPROPANES PHOSPHONATES Alkynylphosphonates ANTI-CANCER Prostate Prostate Cancer Cancer Cyclopropylphophonates Aminophosphonates Cyclopropanes Phosphonates Alkynylphosphonates Anti-Cancer Prostate
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