摘要
<b><span style="font-family:Verdana;">Background: </span></b><span style="font-family:Verdana;">Haematological abnormalities are strong independent predictors of morbidity and mortality in HIV infection.</span><span style="font-family:;" "=""> </span><b><span style="font-family:Verdana;">Objectives of the Study:</span></b><span style="font-family:Verdana;"> This study was carried out to assess the pattern of the changes in the baseline peripheral blood cell counts among adult HIV positive patients. To also determine the </span><span style="font-family:;" "=""><span style="font-family:Verdana;">CD4</span><sup><span style="font-family:Verdana;">+</span></sup></span><span style="font-family:Verdana;"> T</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">cell levels and its correlation with the changes in the baseline cell counts of the patients using HIV negative blood donors as controls.</span><span style="font-family:;" "=""> </span><b><span style="font-family:Verdana;">Methods</span></b><b><span style="font-family:Verdana;">:</span></b><span style="font-family:Verdana;"> This was a case controlled prospective study. The subjects were antiretroviral therapy naive adult HIV positive patients and HIV negative blood donor controls. Five milliliters (5</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">mls) of venous blood was collected from the cubitus of every consecutive consenting subject. Blood sample was analysed for baseline complete blood cell counts and the </span><span style="font-family:;" "=""><span style="font-family:Verdana;">CD4</span><sup><span style="font-family:Verdana;">+</span></sup></span><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">T lymphocyte levels using Sysmex and Cyflow R Counter autoanalysers respectively. Obtained data was analysed with the statistical package for the social scientist (SPSS version 20.0). The Erythrocyte sedimentation rate of subjects was measured by the manual standard Westergreen method. </span><b><span style="font-family:Verdana;">Results: </span></b><span style="font-family:Verdana;">Of 300 subjects, there were 139 (46.3%) males and 161 (53.7%) females in the study. Anaemia was found in 72</span></span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">(29.2%), leucopenia in 20</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">(8%) and thrombocytopenia in 6</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">(2.4%) of the patients. The mean erythrocyte sedimentation rates of the subjects were 81.88</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">mm/hr and 9.46</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">mm/hr (p = 0.000) for the patients and the controls respectively. The mean </span><span style="font-family:;" "=""><span style="font-family:Verdana;">CD4</span><sup><span style="font-family:Verdana;">+</span></sup></span><span style="font-family:Verdana;"> T lymphocyte cell counts were 293</span><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">cells/μl and 750 cells/μl (p = 0.000) for the patients and controls respectively. </span><b><span style="font-family:Verdana;">Conclusion</span></b></span><b><span style="font-family:Verdana;">:</span></b><b><span style="font-family:;" "=""> </span></b><span style="font-family:Verdana;">Anaemia, leucopenia and thrombocytopenia were more prevalent among the studied HIV positive patients.</span>
<b><span style="font-family:Verdana;">Background: </span></b><span style="font-family:Verdana;">Haematological abnormalities are strong independent predictors of morbidity and mortality in HIV infection.</span><span style="font-family:;" "=""> </span><b><span style="font-family:Verdana;">Objectives of the Study:</span></b><span style="font-family:Verdana;"> This study was carried out to assess the pattern of the changes in the baseline peripheral blood cell counts among adult HIV positive patients. To also determine the </span><span style="font-family:;" "=""><span style="font-family:Verdana;">CD4</span><sup><span style="font-family:Verdana;">+</span></sup></span><span style="font-family:Verdana;"> T</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">cell levels and its correlation with the changes in the baseline cell counts of the patients using HIV negative blood donors as controls.</span><span style="font-family:;" "=""> </span><b><span style="font-family:Verdana;">Methods</span></b><b><span style="font-family:Verdana;">:</span></b><span style="font-family:Verdana;"> This was a case controlled prospective study. The subjects were antiretroviral therapy naive adult HIV positive patients and HIV negative blood donor controls. Five milliliters (5</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">mls) of venous blood was collected from the cubitus of every consecutive consenting subject. Blood sample was analysed for baseline complete blood cell counts and the </span><span style="font-family:;" "=""><span style="font-family:Verdana;">CD4</span><sup><span style="font-family:Verdana;">+</span></sup></span><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">T lymphocyte levels using Sysmex and Cyflow R Counter autoanalysers respectively. Obtained data was analysed with the statistical package for the social scientist (SPSS version 20.0). The Erythrocyte sedimentation rate of subjects was measured by the manual standard Westergreen method. </span><b><span style="font-family:Verdana;">Results: </span></b><span style="font-family:Verdana;">Of 300 subjects, there were 139 (46.3%) males and 161 (53.7%) females in the study. Anaemia was found in 72</span></span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">(29.2%), leucopenia in 20</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">(8%) and thrombocytopenia in 6</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">(2.4%) of the patients. The mean erythrocyte sedimentation rates of the subjects were 81.88</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">mm/hr and 9.46</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">mm/hr (p = 0.000) for the patients and the controls respectively. The mean </span><span style="font-family:;" "=""><span style="font-family:Verdana;">CD4</span><sup><span style="font-family:Verdana;">+</span></sup></span><span style="font-family:Verdana;"> T lymphocyte cell counts were 293</span><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">cells/μl and 750 cells/μl (p = 0.000) for the patients and controls respectively. </span><b><span style="font-family:Verdana;">Conclusion</span></b></span><b><span style="font-family:Verdana;">:</span></b><b><span style="font-family:;" "=""> </span></b><span style="font-family:Verdana;">Anaemia, leucopenia and thrombocytopenia were more prevalent among the studied HIV positive patients.</span>
