摘要
<strong>Background:</strong><span style="white-space:normal;font-family:;" "=""> Various thyroid abnormalities have been reported during heart failure (HF). The present study aimed to evaluate the burden, type, and associated factors of thyroid disorders in Cameroonian patients with heart failure. <b>Materials and Methods:</b> We conducted a cross-sectional study from January to May 2020, involving volunteer adults followed for heart failure at the Yaoundé Central Hospital. Those receiving treatment that could cause thyroid dysfunction were excluded. Thyroid hormone levels (TSH, free T3, and free T4) were measured by enzyme-linked immunosorbent assay. <b>Results: </b>A total of 63 patients (30 women;47.6%) were included. The median age was 65 (IQR: 56 </span><span style="white-space:normal;font-family:;" "="">-</span><span style="white-space:normal;font-family:;" "=""> 70) years. The main etiology of heart failure was hypertension</span><span style="white-space:normal;font-family:;" "=""> (52.4%) followed by valvular heart disease (14.3%). Thyroid dysfunction was seen in 38 (60.3%, [95% CI: 47.2 </span><span style="white-space:normal;font-family:;" "="">-</span><span style="white-space:normal;font-family:;" "=""> 72.4]) patients, of which 30 (79%) had hypothyroidism and 8 (21%) had hyperthyroidism. The most frequent thyroid dysfunction was Low T3 syndrome in 27% (95% CI: 16.6 </span><span style="white-space:normal;font-family:;" "="">-</span><span style="white-space:normal;font-family:;" "=""> 39.7) of the study population followed sub-clinical hypothyroidism in 19.1% (95% CI: 10.3 </span><span style="white-space:normal;font-family:;" "="">-</span><span style="white-space:normal;font-family:;" "=""> 30.9) of patients. Patients with HF and reduced ejection fraction (HFrEF) were more likely to have hypothyroidism than those with preserved ejection fraction (OR: 3.5, [95% CI: 1.2 - 9.9], p = 0.016). Also, patients with more than one hospital admission in the past 12 months were more likely to have hypothyroidism (OR: 5.3, [95% CI: 1.3 </span><span style="white-space:normal;font-family:;" "="">-</span><span style="white-space:normal;font-family:;" "=""> 21.5], p = 0.013). <b>Conclusion: </b>The burden of thyroid dysfunction was high in this group of patients with HF. These were mainly low T3 syndrome and sub-clinical hypothyroidism. These were associated with heart failure with reduced ejection fraction and those with more than one hospitalization within the past 12-months</span><span style="white-space:normal;font-family:;" "="">.</span>
<strong>Background:</strong><span style="white-space:normal;font-family:;" "=""> Various thyroid abnormalities have been reported during heart failure (HF). The present study aimed to evaluate the burden, type, and associated factors of thyroid disorders in Cameroonian patients with heart failure. <b>Materials and Methods:</b> We conducted a cross-sectional study from January to May 2020, involving volunteer adults followed for heart failure at the Yaoundé Central Hospital. Those receiving treatment that could cause thyroid dysfunction were excluded. Thyroid hormone levels (TSH, free T3, and free T4) were measured by enzyme-linked immunosorbent assay. <b>Results: </b>A total of 63 patients (30 women;47.6%) were included. The median age was 65 (IQR: 56 </span><span style="white-space:normal;font-family:;" "="">-</span><span style="white-space:normal;font-family:;" "=""> 70) years. The main etiology of heart failure was hypertension</span><span style="white-space:normal;font-family:;" "=""> (52.4%) followed by valvular heart disease (14.3%). Thyroid dysfunction was seen in 38 (60.3%, [95% CI: 47.2 </span><span style="white-space:normal;font-family:;" "="">-</span><span style="white-space:normal;font-family:;" "=""> 72.4]) patients, of which 30 (79%) had hypothyroidism and 8 (21%) had hyperthyroidism. The most frequent thyroid dysfunction was Low T3 syndrome in 27% (95% CI: 16.6 </span><span style="white-space:normal;font-family:;" "="">-</span><span style="white-space:normal;font-family:;" "=""> 39.7) of the study population followed sub-clinical hypothyroidism in 19.1% (95% CI: 10.3 </span><span style="white-space:normal;font-family:;" "="">-</span><span style="white-space:normal;font-family:;" "=""> 30.9) of patients. Patients with HF and reduced ejection fraction (HFrEF) were more likely to have hypothyroidism than those with preserved ejection fraction (OR: 3.5, [95% CI: 1.2 - 9.9], p = 0.016). Also, patients with more than one hospital admission in the past 12 months were more likely to have hypothyroidism (OR: 5.3, [95% CI: 1.3 </span><span style="white-space:normal;font-family:;" "="">-</span><span style="white-space:normal;font-family:;" "=""> 21.5], p = 0.013). <b>Conclusion: </b>The burden of thyroid dysfunction was high in this group of patients with HF. These were mainly low T3 syndrome and sub-clinical hypothyroidism. These were associated with heart failure with reduced ejection fraction and those with more than one hospitalization within the past 12-months</span><span style="white-space:normal;font-family:;" "="">.</span>
作者
Liliane Mfeukeu-Kuate
Honoré Kemnang Yemele
Ahmadou Musa Jingi
Martine Etoa
Jan Rene Nkeck
Jerome Boombhi
Sylvie Ndongo Amougou
Chris Nadege Nganou-Gninjio
Mesmin Yefou Dehayem
Ama Moor Vicky
Liliane Mfeukeu-Kuate;Honoré Kemnang Yemele;Ahmadou Musa Jingi;Martine Etoa;Jan Rene Nkeck;Jerome Boombhi;Sylvie Ndongo Amougou;Chris Nadege Nganou-Gninjio;Mesmin Yefou Dehayem;Ama Moor Vicky(Faculty of Medicine and Biomedical Sciences, The University of Yaounde, Yaounde, Cameroun;The Yaounde Central Hospital, Yaounde, Cameroun;Faculty of Health Sciences, The University of Bamenda, Bamenda, Cameroon;Faculty of Medicine and Pharmaceutical Sciences, The University of Douala, Douala, Cameroun;The Yaounde General Hospital, Yaounde, Cameroon;The Yaounde University Teaching Hospital, Yaounde, Cameroun)
