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Isolation of Multi-Drug Resistant (MDR) and Extensively Drug Resistant (XDR) <i>Salmonella typhi</i>from Blood Samples of Patients Attending Tertiary Medical Centre in Dhaka City, Bangladesh

Isolation of Multi-Drug Resistant (MDR) and Extensively Drug Resistant (XDR) <i>Salmonella typhi</i>from Blood Samples of Patients Attending Tertiary Medical Centre in Dhaka City, Bangladesh
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摘要 <b>Objective:</b> Almost all year round occurrence of typhoid fever remains a major public health issue in Bangladesh. In recent years, there has been a significant rise in the prevalence of multi-drug resistance <i>Salmonella typhi</i> in Dhaka city. The major objective of this study was to observe the prevalence of multi-drug and Extended drug-resistant patterns of typhoidal <i>Salmonella typhi</i> among the patients attending a tertiary medical center by conventional culture and serologic test. <b>Materials and Methods:</b> Blood was collected by syringe and equally divided between aerobic & anaerobic BacT Alert bottle, 10 mL for paediatrics. Post isolation <i>Salmonella</i> strains were identified and were tested for antibiotic resistance. <b>Results:</b> A total of 600 blood samples of typhoid suspected patients were tested, where 32.5% came out positive, which were identified as <i>Salmonella typhi</i>. These isolates were susceptible to carbapenem drugs but highly resistant to Fluoroquinolones and Aminoglycosides antibiotics. <b>Discussion:</b> It was seen that 73.23% of isolates among male patients were extensively drug-resistant (XDR) meaning that isolates were sensitive against only one or two antibiotics while in the female it was 58.46%. Isolates from Female patients showed higher multi-drug resistant (MDR) (26.15%) isolates resistance to multiple antibiotics in comparison to isolates from the male (16.54%). 87.19% of the strains showed high drug resistance (XDR and MDR). <b>Conclusion:</b> The emergence of XDR and MDR strains of <i>S. typhi</i> in recent years is becoming a significant threat. Although no PAN-Drug resistance (resistant against all tested drugs) was observed in the current study, a high level of XDR and MDR isolates are indicating that the scenario might take place sooner than later. <b>Objective:</b> Almost all year round occurrence of typhoid fever remains a major public health issue in Bangladesh. In recent years, there has been a significant rise in the prevalence of multi-drug resistance <i>Salmonella typhi</i> in Dhaka city. The major objective of this study was to observe the prevalence of multi-drug and Extended drug-resistant patterns of typhoidal <i>Salmonella typhi</i> among the patients attending a tertiary medical center by conventional culture and serologic test. <b>Materials and Methods:</b> Blood was collected by syringe and equally divided between aerobic & anaerobic BacT Alert bottle, 10 mL for paediatrics. Post isolation <i>Salmonella</i> strains were identified and were tested for antibiotic resistance. <b>Results:</b> A total of 600 blood samples of typhoid suspected patients were tested, where 32.5% came out positive, which were identified as <i>Salmonella typhi</i>. These isolates were susceptible to carbapenem drugs but highly resistant to Fluoroquinolones and Aminoglycosides antibiotics. <b>Discussion:</b> It was seen that 73.23% of isolates among male patients were extensively drug-resistant (XDR) meaning that isolates were sensitive against only one or two antibiotics while in the female it was 58.46%. Isolates from Female patients showed higher multi-drug resistant (MDR) (26.15%) isolates resistance to multiple antibiotics in comparison to isolates from the male (16.54%). 87.19% of the strains showed high drug resistance (XDR and MDR). <b>Conclusion:</b> The emergence of XDR and MDR strains of <i>S. typhi</i> in recent years is becoming a significant threat. Although no PAN-Drug resistance (resistant against all tested drugs) was observed in the current study, a high level of XDR and MDR isolates are indicating that the scenario might take place sooner than later.
作者 Oshin Ghurnee Amit Kumar Ghosh Maruf Abony Shahrin Akhter Aurin Aneeka Nawar Fatema Avijit Banik Zakaria Ahmed Oshin Ghurnee;Amit Kumar Ghosh;Maruf Abony;Shahrin Akhter Aurin;Aneeka Nawar Fatema;Avijit Banik;Zakaria Ahmed(Department of Microbiology, Primeasia University, Dhaka, Bangladesh;Microbiology Department, Technology Wing, Bangladesh Jute Research Institute, Dhaka, Bangladesh)
出处 《Advances in Microbiology》 2021年第9期488-498,共11页 微生物学(英文)
关键词 MDR XDR <i>S. typhi</i> Blood Samples Typhoid Fever BANGLADESH MDR XDR <i>S. typhi</i> Blood Samples Typhoid Fever Bangladesh
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