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The Protective and Recovery Effects of Fish Oil Supplementation on Cedar Pollen-Induced Allergic Reactions in Mice

The Protective and Recovery Effects of Fish Oil Supplementation on Cedar Pollen-Induced Allergic Reactions in Mice
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摘要 Obesity is associated with the production of pro-inflammatory cytokines and therefore can lead to worsening of allergic reactions. Thus, there is cross-talk between obesity and allergic reactions. In this study, we investigated whether the anti-obesity action of fish oil supplementation is involved in the anti-allergic action also induced by fish oil. We observed attenuation of cedar pollen-induced IgE serum increases in two experimental protocols: 15% fish oil supplementation for 8 weeks, which attenuated body weight increases compared with 15% soybean supplementation, and 4% fish oil supplementation for 2 weeks, which did not affect body weight increases compared with 4% soybean or 4% lard supplementation. The former but not the latter protocol attenuated sneezing after pollen challenge. Gene expression of TNF-α and IL-13, a Th2 cytokine, was moderately reduced in the trachea and nasal mucosa in mice fed fish oil supple- ments. In a third protocol, fish oil was administered for up to 15 weeks after a cedar pollen sensitization and challenge-induced increase in IgE levels. These levels decreased following fish oil supplementation but were almost unaffected by soybean oil supplementation. Surprisingly, the IL-13 gene expression level in the nasal mucosa and trachea was higher in the fish oil group than in the soybean oil group. These results suggest that fish oil supplementation before, during, or after antigen sensitization and challenge in mice helped to reduce cedar pollen-induced allergic reactions in- dependent of its anti-obesity action. Fish oil supplementation can also exhibit pro- or anti-inflammatory action against IL-13 expression depending on the experimental protocol. Obesity is associated with the production of pro-inflammatory cytokines and therefore can lead to worsening of allergic reactions. Thus, there is cross-talk between obesity and allergic reactions. In this study, we investigated whether the anti-obesity action of fish oil supplementation is involved in the anti-allergic action also induced by fish oil. We observed attenuation of cedar pollen-induced IgE serum increases in two experimental protocols: 15% fish oil supplementation for 8 weeks, which attenuated body weight increases compared with 15% soybean supplementation, and 4% fish oil supplementation for 2 weeks, which did not affect body weight increases compared with 4% soybean or 4% lard supplementation. The former but not the latter protocol attenuated sneezing after pollen challenge. Gene expression of TNF-α and IL-13, a Th2 cytokine, was moderately reduced in the trachea and nasal mucosa in mice fed fish oil supple- ments. In a third protocol, fish oil was administered for up to 15 weeks after a cedar pollen sensitization and challenge-induced increase in IgE levels. These levels decreased following fish oil supplementation but were almost unaffected by soybean oil supplementation. Surprisingly, the IL-13 gene expression level in the nasal mucosa and trachea was higher in the fish oil group than in the soybean oil group. These results suggest that fish oil supplementation before, during, or after antigen sensitization and challenge in mice helped to reduce cedar pollen-induced allergic reactions in- dependent of its anti-obesity action. Fish oil supplementation can also exhibit pro- or anti-inflammatory action against IL-13 expression depending on the experimental protocol.
机构地区 不详
出处 《Food and Nutrition Sciences》 2012年第1期40-47,共8页 食品与营养科学(英文)
关键词 CYTOKINE Fish Oil IGE OBESITY POLLEN ALLERGY Cytokine Fish Oil IgE Obesity Pollen Allergy
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  • 1Fujiwara H, Terashima M, lrinoda T, et al. Quantitative measurement of thymidylate synthase and dihydropyrimidinedehydrogenase mRNA level in gastric cancer hy real-time RT-PCR [J]. Jpn J Cancer Res, 2002, 93(12): 1342-1350.
  • 2Levi F. Circadian chronotherapy for human cancers [J]. Lancet Oncol, 2001, 2(5): 307-315.
  • 3Levi F. From circadian rhythms to cancer chronotherapeutics [J]. Chronobiol Int, 2002; 19(1): 1-19.
  • 4Li Yan, Schlamp CL, Poulsen GL, et al. p53 regulates apoptotic retinal ganglion cell death induced by N-methyl-D-aspartate[J].Molecular Vision, 2002, 8:341-350.
  • 5suppressesMondal D, Agrawal KC granuloeyte-monoeyteZidovudine (AZT) treatment colony stimulating factor receptor type alpha (GM-CSFR alpha) gene expression in murineb one marrow cells [J]. Life Sci, 2002, 71(8): 967 -978.
  • 6Porsin B, Formento JL, Filipski E, et al. Dihydropyrimidine dehydrogenase circadian rhythtn in mouse liver: comparison between enzyme activity and gene expression [J]. Eur J Cancer,2003, 39(6): 822-828.
  • 7Nelson W, Tong Y, Lee JK, et al. Methods for cosinor rhythmometry [J]. Chronobiologia. 1979, 6:305-323.
  • 8Filipski E, King VM, Li XM, et al. Host circadian clock as a control point in tumor progression [J]. J Nat Cancer Inst, 2002,94(9): 690-697.
  • 9Chen YP, Higgins JA, Gundersen-Rindal DE. Quantitation of a Glyptapanteles indiensis polydnavirus gene expressed in parasitized host, Lymantria dispar, by real-time quantitative RT-PCR [J]. J Virol Methods, 2003, 114(2):125-133.
  • 10Neuvians TP, Sehams D, Berisha B, et al. Involvement of Pro-Inflammatory Cytokines, Mediators of Inflammation, and Basic Fibroblast Growth Factor in Prostaglandin F2{alpha} -Induced Luteolysis in Bovine Corpus Luteum [J], Biol Reprod,2003 perssed online.

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