摘要
Background and Objective: HIV, hepatitis B virus (HBV) and hepatitis C virus (HCV) are very widespread in the world, however, less than 20% of the people affected are diagnosed and treated. This study aimed to determine the prevalence of HIV, HCV and HBV co-infections in pregnant women at Bangui Community University Hospital and the cost of screening. Methods: A cross-sectional study involving consenting pregnant women who came for antenatal care was performed. HIV, HCV antibodies and HBV antigens were detected using Exacto Triplex<sup>?</sup> HIV/HCV/HBsAg rapid test, cross-validated by ELISA tests. Sociodemographic and professional data, the modes of transmission and prevention of HIV and both hepatitis viruses were collected in a standard sheet and analyzed using the Epi-Info software version 7. Results: Pregnant women aged 15 to 24 were the most affected (45.3%);high school girls (46.0%), and pregnant women living in cohabitation (65.3%) were the most represented. Twenty-five (16.7%) worked in the formal sector, 12.7% were unemployed housewives and the remainder in the informal sector. The prevalence of HIV, HBV, and HCV viruses was 11.8%, 21.9% and 22.2%, respectively. The prevalence of co-infections was 8.6% for HIV-HBV, 10.2% for HIV-HCV, 14.7% for HBV-HCV and 6.5% for HIV-HBV-HCV. All positive results and 10% of negative results by the rapid test were confirmed by ELISA tests. The serology of the three viruses costs 39,000 FCFA (60 Euros) by ELISA compared to 10,000 FCFA (15.00 Euros) with Exacto Triplex<sup>?</sup> HIV/HCV/AgHBs (BioSynex, Strasbourg, France). Conclusion: The low level of education and awareness of hepatitis are barriers to development and indicate the importance of improving the literacy rate of women in the Central African Republic (CAR). Likewise, the high prevalence of the three viruses shows the need for the urgent establishment of a national program to combat viral hepatitis in the CAR.
Background and Objective: HIV, hepatitis B virus (HBV) and hepatitis C virus (HCV) are very widespread in the world, however, less than 20% of the people affected are diagnosed and treated. This study aimed to determine the prevalence of HIV, HCV and HBV co-infections in pregnant women at Bangui Community University Hospital and the cost of screening. Methods: A cross-sectional study involving consenting pregnant women who came for antenatal care was performed. HIV, HCV antibodies and HBV antigens were detected using Exacto Triplex<sup>?</sup> HIV/HCV/HBsAg rapid test, cross-validated by ELISA tests. Sociodemographic and professional data, the modes of transmission and prevention of HIV and both hepatitis viruses were collected in a standard sheet and analyzed using the Epi-Info software version 7. Results: Pregnant women aged 15 to 24 were the most affected (45.3%);high school girls (46.0%), and pregnant women living in cohabitation (65.3%) were the most represented. Twenty-five (16.7%) worked in the formal sector, 12.7% were unemployed housewives and the remainder in the informal sector. The prevalence of HIV, HBV, and HCV viruses was 11.8%, 21.9% and 22.2%, respectively. The prevalence of co-infections was 8.6% for HIV-HBV, 10.2% for HIV-HCV, 14.7% for HBV-HCV and 6.5% for HIV-HBV-HCV. All positive results and 10% of negative results by the rapid test were confirmed by ELISA tests. The serology of the three viruses costs 39,000 FCFA (60 Euros) by ELISA compared to 10,000 FCFA (15.00 Euros) with Exacto Triplex<sup>?</sup> HIV/HCV/AgHBs (BioSynex, Strasbourg, France). Conclusion: The low level of education and awareness of hepatitis are barriers to development and indicate the importance of improving the literacy rate of women in the Central African Republic (CAR). Likewise, the high prevalence of the three viruses shows the need for the urgent establishment of a national program to combat viral hepatitis in the CAR.
作者
Catherine Boni-Cisse
Nina Esther Onstira Ngoyi
Hermione Dahlia Mossoro-Kpinde
Noella Packo
Rabi Senekian
Hermann Ndoidet Koutou
Coretha Bokia-Baguida
Christelle Luce Bobossi-Gadia
Arthur Simplice Sombot-Ndicky
Daniel Yvon Gonessa
Freddy Samuel Ngbonga Konzapa Voulou
Christian Diamant Mossoro-Kpinde
Catherine Boni-Cisse;Nina Esther Onstira Ngoyi;Hermione Dahlia Mossoro-Kpinde;Noella Packo;Rabi Senekian;Hermann Ndoidet Koutou;Coretha Bokia-Baguida;Christelle Luce Bobossi-Gadia;Arthur Simplice Sombot-Ndicky;Daniel Yvon Gonessa;Freddy Samuel Ngbonga Konzapa Voulou;Christian Diamant Mossoro-Kpinde(Alassane OUATTARA National Center of Medical Oncology and Radiotherapy, Abidjan, Ivory Cost;Department of Microbiology, UFR of Medical Sciences, University of Cocody, Abidjan, Ivory Cost;Laboratory of Bacteriology-Virology of Teaching Hospital Center of Brazzaville, Brazzaville, Republic of Congo;Faculty of Health Sciences, Marien NGOUABI University, Brazzaville, Republic of Congo;Department of Labor Medicine, Service of HIV and STDs Control in the Workplace, Bangui, Central African Republic (CAR);Faculty of Health Sciences, University of Bangui, Bangui, Central African Republic;National Reference Center of Sexually Transmitted Diseases and Antiretroviral Therapy, Bangui, Central African Republic;National Laboratory of Clinical Biology and Public Health, Bangui, Central African Republic;Medicine Department, District Hospital of Alindao, Alindao, Ouaka Prefecture, Central African Republic;Doctoral School of Sciences and Technology, University of Bangui, Bangui, Central African Republic;Coordination of Specialized Study of Clinical Biology, University of Bangui, Bangui, Central African Republic;Doctors without Borders Hospital Sica, Bangui,CRA;Laboratory of Medical Analysis of Teaching Hospital Center Mother Elisabeth DOMITIEN of Bimbo, Bimbo, Central African Republic)
