摘要
三阴性乳腺癌占乳腺癌总数的15％～20％,是乳腺癌中最具侵袭力的一种特殊亚型,其雌激素受体、孕激素受体及人类表皮生长因子受体2表达缺失.三阴性乳腺癌患者从乳腺癌的传统治疗方法中获益有限,预后很差,因此,迫切需要寻找到新的治疗方法.本文主要介绍三阴性乳腺癌相关的PIM1、MYC、CDK4、TGF-β、TP53、MYOF、FOSB、MENA等基因和蛋白表达特点,以及和PARP、PI3K/Akt/mTOR、EGFR、Hedgehog、Met等有关的靶向治疗的最新研究进展.
Triple-negative breast cancer,which lacks estrogen receptor,progesterone receptor,and human epidermal growth factor receptor 2,accounts for about 15％-20％ of breast cancers,and is the most aggressive breast cancer subtype.It displays poor prognosis from traditional therapies,therefore,there is an urgent need to find new treatments.This paper mainly describes the characteristics of protein and gene expression,such as PIM1,MYC,CDK4,TGF-β,TP53,MYOF,FOSB,MENA,and the latest research of therapeutic approaches of triplenegative breast cancer about PARP,PI3K/Akt/mTOR,EGFR,Hedgehog,Met,etc..
出处
《国际外科学杂志》
2017年第10期709-714,共6页
International Journal of Surgery
关键词
乳腺肿瘤
三阴性
基因
蛋白质
治疗
Breast neoplasms,triple-negative
Genes
Protein
Therapy
