摘要
目的：探讨地佐辛治疗晚期癌症患者伴中度及重度疼痛的临床疗效，分析其临床应用安全性。方法选取2014年6月至2015年6月我院收治的90例晚期癌症患者，所有患者均伴有中度及重度疼痛。两组患者均给予镇痛药物治疗，对照组肌内注射10 mg 盐酸吗啡注射液，每隔3～6 h 注射药物1次。观察组肌内注射10 mg 地佐辛注射液，每隔3～6 h 注射药物1次。对比两组镇痛效果（显效、有效、部分有效及无效）、不良反应发生情况（恶心、呕吐、眩晕、呼吸抑制、排尿困难或便秘）及生活质量（包括食欲、睡眠、情绪等），其中镇痛效果与不良反应发生率采用百分比表示，比较应用χ2检验；生活质量采用均数±标准差（ sx ±）表示，比较采用配对 t 检验，P＜0.05为差异具有统计学意义。结果观察组镇痛有效率为86.67%，对照组为88.89%，两组相比差异无统计学意义（P＞0.05）；对照组与观察组治疗前生活质量评分分别为（23.5±1.7）分，（24.1±2.1）分，差异无统计学意义（P＞0.05）；治疗后，两组生活质量评分各为（34.7±1.8）分，（35.2±1.5）分，差异无统计学意义（P＞0.05）；但与治疗前相比，两组患者生活质量评分均明显增加，差异具有统计学意义（P＜0.05）。观察组不良反应发生率明显低于对照组（13.33% vs.33.33%），差异具有统计学意义（P＜0.05）。结论地佐辛与吗啡在减轻患者疼痛、改善患者生活质量等方面疗效相近，但地佐辛不良反应较轻，成瘾小，具有显著的推广优势。
Objective To investigate the clinical efficacy of dezocine in treatment of advanced cancer patients with moderate and severe pain, and to analyze its clinical safety. Methods 90 advanced cancer patients with moderate and severe pain admitted into our hospital from June 2014 to June 2015 were selected. Two groups were given analgesic drug, control group was given intramuscular injection of 10 mg morphine hydrochloride injection, one injection every 3-6 h. Observation group was given intramuscular injection of 10 mg dezocine injection, one injection every 3-6 h. The analgesic effects (obvious effect, effect, partial effect and no effect), adverse reactions (nausea, vomiting, vertigo, respiratory depression, dysuria or constipation), living quality (appetite, sleep, emotion) of two groups were compared. The analgesic effects and incidence of adverse reactions were expressed as a percentage, χ2 test was took and living quality was expressed as x ± , and in paired t test, P<0.05 was took as difference and had statistical s significance. Results The analgesic effective rate of observation group was 86.67%, control group was 88.89%, and there was no significant difference between the two groups (P>0.05); Before treatment, the living quality scores of control group and observation group were (23.5±1.7) points, (24.1±2.1) points respectively, there was no significant difference (P>0.05); After treatment, the living quality scores of two groups were (34.7±1.8) points, (35.2±1.5) points respectively, there was no significant difference (P>0.05);Compared with pre-treatment, the living quality scores of two groups significantly increased (P<0.05). The incidence of adverse reactions in observation group was significantly lower than that in control group (13.33%<33.33%) (P<0.05). Conclusion Dezocine and morphine have similar efficacy in reducing pain and improving living quality, but dezocine has slighter adverse reactions and small addiction, which has remarkably promotional advantages.
出处
《中华临床医师杂志（电子版）》
CAS
2016年第24期-,共4页
Chinese Journal of Clinicians(Electronic Edition)
