下肢深静脉血栓(lower extremity deep venous thrombosis,LDVT)由下肢深静脉腔内的血液流速减慢、血管内壁炎性刺激等导致血液在血管内异常凝结造成,主要不良后果是肺动脉血栓栓塞和血栓形成后综合征,不仅严重影响患者生活质量,危重情...下肢深静脉血栓(lower extremity deep venous thrombosis,LDVT)由下肢深静脉腔内的血液流速减慢、血管内壁炎性刺激等导致血液在血管内异常凝结造成,主要不良后果是肺动脉血栓栓塞和血栓形成后综合征,不仅严重影响患者生活质量,危重情况下甚至可能导致死亡。尽管LDVT备受关注,但是早期的模型对危险因素的评估并不充分和详细,导致临床无法及时有效地预防LDVT,患病率仍逐年上升,其中围绝经期和绝经期妇女LDVT发生率较高~([1])。本研究为了进一步探明围绝经期及绝经期全子宫切除后LDVT形成的关键因素,回顾性分析141例全子宫切除患者的临床资料,探讨其术后发生LDVT的影响因素,并构建一种有效可靠的预测工具,现报道如下。展开更多
In the present study,we retrospectively analyzed 105382 prescriptions of antipyretic drugs for children(0–14 years of age)in the outpatient and emergency departments of Ningbo Women and Children’s Hospital from Janu...In the present study,we retrospectively analyzed 105382 prescriptions of antipyretic drugs for children(0–14 years of age)in the outpatient and emergency departments of Ningbo Women and Children’s Hospital from January to December 2019.Ibuprofen and acetaminophen are relatively safe and the most commonly used drugs in daily life.Due to different dosage forms,there are acetaminophen suspension drops,acetaminophen oral solution,ibuprofen suspension,and ibuprofen suppositories for children.Through investigation,we found that the age of antipyretic drugs used by children in our hospital ranged from 3 months to 14 years old,which could be divided into two groups:single drug use and alternating use of ibuprofen and acetaminophen,with an alternating use rate of 3.19%.There were differences between the two groups in terms of age,gender,the proportion of emergency departments use,and the amount of single prescription(P<0.05).The age of the alternating use group was younger,and the male proportion,the proportion of emergency departments use,single prescription amount of the alternating use group were higher.In the alternating use group,ibuprofen and acetaminophen of different dosage forms were used alternatively.After pair comparison analysis,they only had an age difference(P<0.008),which was in line with the principle that different dosage forms are suitable for different ages.The method of alternation with ibuprofen and acetaminophen is mainly used in the emergency departments and children of younger age because most of the children have a refractory fever,which is complicated and changes relatively fast.There was no record of adverse reactions about alternation of ibuprofen and acetaminophen in the software system of adverse reactions.However,this study was a retrospective analysis,and there were risks of missing records.Therefore,alternating use of ibuprofen and acetaminophen still couldn’t ignore the risk of adverse reactions.展开更多
文摘下肢深静脉血栓(lower extremity deep venous thrombosis,LDVT)由下肢深静脉腔内的血液流速减慢、血管内壁炎性刺激等导致血液在血管内异常凝结造成,主要不良后果是肺动脉血栓栓塞和血栓形成后综合征,不仅严重影响患者生活质量,危重情况下甚至可能导致死亡。尽管LDVT备受关注,但是早期的模型对危险因素的评估并不充分和详细,导致临床无法及时有效地预防LDVT,患病率仍逐年上升,其中围绝经期和绝经期妇女LDVT发生率较高~([1])。本研究为了进一步探明围绝经期及绝经期全子宫切除后LDVT形成的关键因素,回顾性分析141例全子宫切除患者的临床资料,探讨其术后发生LDVT的影响因素,并构建一种有效可靠的预测工具,现报道如下。
基金Ningbo Clinical Research Center for Children’s He alth and Diseases(Grant No.2019A21002)Ningbo Medical Science and Technology Project(Grant No.2020Y15)。
文摘In the present study,we retrospectively analyzed 105382 prescriptions of antipyretic drugs for children(0–14 years of age)in the outpatient and emergency departments of Ningbo Women and Children’s Hospital from January to December 2019.Ibuprofen and acetaminophen are relatively safe and the most commonly used drugs in daily life.Due to different dosage forms,there are acetaminophen suspension drops,acetaminophen oral solution,ibuprofen suspension,and ibuprofen suppositories for children.Through investigation,we found that the age of antipyretic drugs used by children in our hospital ranged from 3 months to 14 years old,which could be divided into two groups:single drug use and alternating use of ibuprofen and acetaminophen,with an alternating use rate of 3.19%.There were differences between the two groups in terms of age,gender,the proportion of emergency departments use,and the amount of single prescription(P<0.05).The age of the alternating use group was younger,and the male proportion,the proportion of emergency departments use,single prescription amount of the alternating use group were higher.In the alternating use group,ibuprofen and acetaminophen of different dosage forms were used alternatively.After pair comparison analysis,they only had an age difference(P<0.008),which was in line with the principle that different dosage forms are suitable for different ages.The method of alternation with ibuprofen and acetaminophen is mainly used in the emergency departments and children of younger age because most of the children have a refractory fever,which is complicated and changes relatively fast.There was no record of adverse reactions about alternation of ibuprofen and acetaminophen in the software system of adverse reactions.However,this study was a retrospective analysis,and there were risks of missing records.Therefore,alternating use of ibuprofen and acetaminophen still couldn’t ignore the risk of adverse reactions.
