Building data mining application platform in telecommunications industry can take full advantage of business data in telecommunication systems to explore the potential patterns in user behavior and business trends, th...Building data mining application platform in telecommunications industry can take full advantage of business data in telecommunication systems to explore the potential patterns in user behavior and business trends, thereby providing more effective decision support to help enterprises cope with increasingly fierce industry competitions.This paper discusses data mining architecture and business demand for data mining in telecommunications industry,and on this basis puts forward an SOA-based data mining application platform solutions in telecommunications industry with the characteristic of integration,flexibility,and customization.展开更多
目的探究Tim-3/Galectin-9负性信号通路在亲缘HLA单倍体相合外周血造血干细胞移植中的变化特点及其临床意义。方法以行单倍体造血干细胞移植的36例患者和20例健康者为研究对象,通过FCM监测患者及健康对照组外周血中CD4^(+)T细胞和Tim-3...目的探究Tim-3/Galectin-9负性信号通路在亲缘HLA单倍体相合外周血造血干细胞移植中的变化特点及其临床意义。方法以行单倍体造血干细胞移植的36例患者和20例健康者为研究对象,通过FCM监测患者及健康对照组外周血中CD4^(+)T细胞和Tim-3分子的表达情况,ELISA法检测移植后患者细胞因子Galectin-9、IFN-γ、IL-4、TGF-β和IL-17的动态变化。结果根据西雅图国际诊断标准,移植术后有14例患者发生aGVHD,22例患者未发生aGVHD。①未发生aGVHD患者移植后30~90 d CD4^(+)T细胞百分比均低于健康对照组(P<0.05);未发生aGVHD患者移植后血清中细胞因子Galectin-9、TGF-β、IFN-γ、IL-4和IL-17水平呈现逐渐增高的趋势,Galectin-9和TGF-β水平在移植后60 d达到正常值(P>0.05),IFN-γ、IL-4和IL-17在移植后第90天恢复到正常水平(P>0.05)。Spearman相关分析结果显示Galectin-9与TGF-β变化水平呈正相关(r=0.651,P=0.001);②发生aGVHD患者外周血中Tim-3^(+)CD4^(+)T细胞的百分比和IFN-γ、IL-17水平明显高于不发生aGVHD患者(P<0.01);不发生aGVHD患者的Galectin-9和TGF-β水平更高(P<0.05)。Spearman相关分析结果显示Tim-3^(+)CD4^(+)T细胞的百分比与IFN-γ水平呈正相关(r=0.631,P=0.015)。结论单倍体相合外周血造血干细胞移植后细胞因子Galectin-9和TGF-β的早期快速重建可以避免或减缓aGVHD的发生,移植后动态监测Tim-3^(+)CD4^(+)T细胞持续较多而血清中Galectin-9水平下降可能预示着aGVHD的发生。展开更多
文摘Building data mining application platform in telecommunications industry can take full advantage of business data in telecommunication systems to explore the potential patterns in user behavior and business trends, thereby providing more effective decision support to help enterprises cope with increasingly fierce industry competitions.This paper discusses data mining architecture and business demand for data mining in telecommunications industry,and on this basis puts forward an SOA-based data mining application platform solutions in telecommunications industry with the characteristic of integration,flexibility,and customization.
文摘目的探究Tim-3/Galectin-9负性信号通路在亲缘HLA单倍体相合外周血造血干细胞移植中的变化特点及其临床意义。方法以行单倍体造血干细胞移植的36例患者和20例健康者为研究对象,通过FCM监测患者及健康对照组外周血中CD4^(+)T细胞和Tim-3分子的表达情况,ELISA法检测移植后患者细胞因子Galectin-9、IFN-γ、IL-4、TGF-β和IL-17的动态变化。结果根据西雅图国际诊断标准,移植术后有14例患者发生aGVHD,22例患者未发生aGVHD。①未发生aGVHD患者移植后30~90 d CD4^(+)T细胞百分比均低于健康对照组(P<0.05);未发生aGVHD患者移植后血清中细胞因子Galectin-9、TGF-β、IFN-γ、IL-4和IL-17水平呈现逐渐增高的趋势,Galectin-9和TGF-β水平在移植后60 d达到正常值(P>0.05),IFN-γ、IL-4和IL-17在移植后第90天恢复到正常水平(P>0.05)。Spearman相关分析结果显示Galectin-9与TGF-β变化水平呈正相关(r=0.651,P=0.001);②发生aGVHD患者外周血中Tim-3^(+)CD4^(+)T细胞的百分比和IFN-γ、IL-17水平明显高于不发生aGVHD患者(P<0.01);不发生aGVHD患者的Galectin-9和TGF-β水平更高(P<0.05)。Spearman相关分析结果显示Tim-3^(+)CD4^(+)T细胞的百分比与IFN-γ水平呈正相关(r=0.631,P=0.015)。结论单倍体相合外周血造血干细胞移植后细胞因子Galectin-9和TGF-β的早期快速重建可以避免或减缓aGVHD的发生,移植后动态监测Tim-3^(+)CD4^(+)T细胞持续较多而血清中Galectin-9水平下降可能预示着aGVHD的发生。
