目的:探讨^(68)Ga标记的成纤维细胞激活蛋白抑制剂(fibroblast activation protein inhibitor,FAPI)-04正电子发射断层显像/X线计算机体层成像(positron emission tomography and computed tomography,PET/CT)对初诊胰腺癌的诊断价值及...目的:探讨^(68)Ga标记的成纤维细胞激活蛋白抑制剂(fibroblast activation protein inhibitor,FAPI)-04正电子发射断层显像/X线计算机体层成像(positron emission tomography and computed tomography,PET/CT)对初诊胰腺癌的诊断价值及对肿瘤分期的影响。方法:回顾性收集2021年8月至2023年8月于重庆大学附属肿瘤医院就诊的134例因怀疑胰腺占位的患者临床及影像资料。分析^(68)Ga-FAPI-04 PET/CT对胰腺癌原发灶及转移灶的诊断价值;并与传统CT比较,分析^(68)Ga-FAPI-04 PET/CT对胰腺癌肿瘤分期的影响。结果:共计纳入134例患者,其中胰腺癌127例,良性病变7例。^(68)Ga-FAPI-04 PET/CT对胰腺癌原发灶、区域淋巴结及远处转移灶检出率分别为100%(127/127)、68.63%(35/51),95.35%(41/43)。胰腺癌中位最大标准化摄取值(standard uptake value maxium,SUVmax)为14.92,高于胰腺良性病变中位SUVmax(6.1)(Z=−2.921,P=0.003)。与传统CT比较,^(68)Ga-FAPI PET/CT检查后共有32.28%(41/127)胰腺癌患者TNM分期发生改变。3.94%(5/127)患者改变了治疗方案。结论:^(68)Ga-FAPI-04 PET/CT对胰腺癌原发灶诊断具有较高的敏感性,较传统CT可发现更多远处转移病灶,改善患者M分期,有助于全面评估全身肿瘤负荷、制定治疗计划。展开更多
The structure of light diquarks plays a crucial role in formation of exotic hadrons beyond the conventional quark model, especially with regard to the line shapes of bottomed hadron decays. We study the two-body hadro...The structure of light diquarks plays a crucial role in formation of exotic hadrons beyond the conventional quark model, especially with regard to the line shapes of bottomed hadron decays. We study the two-body hadronic weak decays of bottomed baryons and bottomed mesons to probe the light diquark structure and to pin down the quark–quark correlations in the diquark picture. It is found that the light diquark does not favor a compact structure. For instance, the isoscalar diquark [ud] in Λ_(b)^(0) can be easily split and rearranged to form ■via the color-suppressed transition. This provides a hint that the hidden charm pentaquark states produced in Λ_(b)^(0) decays could be the ■chadronic molecular candidates. This quantitative study resolves the apparent conflicts between the production mechanism and the molecular nature of these P_(c) states observed in experiment.展开更多
基金partly supported by the National Natural Science Foundation of China (Grant Nos. 12375073, 12035007, 12205106, and 12105028)Guangdong Provincial Fund (Grant No. 2019QN01X172)+2 种基金Guangdong Major Project of Basic and Applied Basic Research (Grant No. 2020B0301030008)the NSFC and the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) through the funds provided to the Sino-German Collaborative Research Center TRR110 “Symmetries and the Emergence of Structure in QCD” (NSFC Grant No. 12070131001, DFG Project-ID 196253076-TRR 110)supported by the Natural Science Foundation of Jiangsu Province (Grant No. BK20200980)
文摘The structure of light diquarks plays a crucial role in formation of exotic hadrons beyond the conventional quark model, especially with regard to the line shapes of bottomed hadron decays. We study the two-body hadronic weak decays of bottomed baryons and bottomed mesons to probe the light diquark structure and to pin down the quark–quark correlations in the diquark picture. It is found that the light diquark does not favor a compact structure. For instance, the isoscalar diquark [ud] in Λ_(b)^(0) can be easily split and rearranged to form ■via the color-suppressed transition. This provides a hint that the hidden charm pentaquark states produced in Λ_(b)^(0) decays could be the ■chadronic molecular candidates. This quantitative study resolves the apparent conflicts between the production mechanism and the molecular nature of these P_(c) states observed in experiment.
