[Objective] The paper was to study in vitro pharmacodynamics characteristics of florfenicol dual suspension emulsion (DSEF). [Method] The florfenicol injection (FI) was used as the control group, the minimal inhibitor...[Objective] The paper was to study in vitro pharmacodynamics characteristics of florfenicol dual suspension emulsion (DSEF). [Method] The florfenicol injection (FI) was used as the control group, the minimal inhibitory concentration (MIC), minimal bactericide concentration (MBC) and mutant selection window (MSW) of florfenicol dual suspension emulsion on 5 kinds of bacteria were determined. The post-antibiotic effect (PAE) and post-antibiotic sub-MIC effect (PASME) of Salmonella typhimurium were also measured. [Result] Compared with the ordinary injection, the MIC and MBC of florfenicol dual suspension emulsion on 5 kinds of bacteria showed no obvious changes. However, florfenicol dual suspension emulsion obviously narrowed MSW of 5 kinds of bacteria (P<0.01), which also significantly extended PAE and PASME of S. typhimurium (P<0.01). [Conclusion] The florfenicol dual suspension emulsion in vitro can reduce the probability of bacterial resistance, significantly prolong after effect time of antibiotics on bacteria, thereby effectively improving the antibacterial effect.展开更多
文摘[Objective] The paper was to study in vitro pharmacodynamics characteristics of florfenicol dual suspension emulsion (DSEF). [Method] The florfenicol injection (FI) was used as the control group, the minimal inhibitory concentration (MIC), minimal bactericide concentration (MBC) and mutant selection window (MSW) of florfenicol dual suspension emulsion on 5 kinds of bacteria were determined. The post-antibiotic effect (PAE) and post-antibiotic sub-MIC effect (PASME) of Salmonella typhimurium were also measured. [Result] Compared with the ordinary injection, the MIC and MBC of florfenicol dual suspension emulsion on 5 kinds of bacteria showed no obvious changes. However, florfenicol dual suspension emulsion obviously narrowed MSW of 5 kinds of bacteria (P<0.01), which also significantly extended PAE and PASME of S. typhimurium (P<0.01). [Conclusion] The florfenicol dual suspension emulsion in vitro can reduce the probability of bacterial resistance, significantly prolong after effect time of antibiotics on bacteria, thereby effectively improving the antibacterial effect.
