目的通过Meta分析方法系统评价不同研究中小剂量他克莫司治疗重症肌无力患者的疗效及安全性。方法计算机检索Elsevier Sciencedirect、Web of Science、Pubmed、中国知网数据库知(CNKI)、万方数据库及维普中文科技期刊数据库,全面搜索...目的通过Meta分析方法系统评价不同研究中小剂量他克莫司治疗重症肌无力患者的疗效及安全性。方法计算机检索Elsevier Sciencedirect、Web of Science、Pubmed、中国知网数据库知(CNKI)、万方数据库及维普中文科技期刊数据库,全面搜索他克莫司治疗重症肌无力相关文献。使用Rev Man5.3软件对提取资料进行统计分析。结果 3篇对照试验文献分析结果显示,他克莫司跟对照组相比不能显著降低重症肌无力的QMG评分[MDIV(95%CI)=-0.91(-8.37,6.55),Z=0.24(P=0.81)];他克莫司治疗组不良反应发生率和对照组无统计学意义[OR(95%CI)=1.29(0.59,2.81),Z=0.64(P=0.52)];分析其余自身对照试验文献显示,加用他克莫司可以显著改善重症肌无力的严重程度[亚洲组:MDIV(95%CI)=-8.16(-10.61,-5.72),Z=6.55(P<0.01);欧洲组:MD IV(95%CI)=-20.49(-21.40,-19.57),Z=43.80(P<0.01)]。结论研究结果显示加用小剂量他克莫司可短期改善重症肌无力患者的严重程度,安全性可靠。受纳入研究文献质量限制,他克莫司的安全性及有效性仍需要大型多中心随机对照研究及基于高质量文献的meta分析来认证。展开更多
Three questions are discussed in this paper:1)the factors which influenced in composting refuse, 2)the biology effect in composting refuse, 3)the useful of the composted refuse in agriculture and environment protectio...Three questions are discussed in this paper:1)the factors which influenced in composting refuse, 2)the biology effect in composting refuse, 3)the useful of the composted refuse in agriculture and environment protection. Ref展开更多
This paper presents a review with 41 references on bioremediation ofoilor oil products contaminat ed soil and groundwaterin the past several years. Many aspects are discussed ,such as the types of remediedsoils ,the d...This paper presents a review with 41 references on bioremediation ofoilor oil products contaminat ed soil and groundwaterin the past several years. Many aspects are discussed ,such as the types of remediedsoils ,the degraded pollutants,separation and selection ofstrainsfor oil degradation ,effects ofthe added nutri tion or other substances ,and some available techniques of bioremediation .展开更多
文摘Three questions are discussed in this paper:1)the factors which influenced in composting refuse, 2)the biology effect in composting refuse, 3)the useful of the composted refuse in agriculture and environment protection. Ref
文摘This paper presents a review with 41 references on bioremediation ofoilor oil products contaminat ed soil and groundwaterin the past several years. Many aspects are discussed ,such as the types of remediedsoils ,the degraded pollutants,separation and selection ofstrainsfor oil degradation ,effects ofthe added nutri tion or other substances ,and some available techniques of bioremediation .
