肝脏疾病与妊娠临床上表现为相互影响的重要关系。妊娠相关性肝病是妊娠期肝损伤的最常见原因,并且对母亲和胎儿的生存构成严重威胁。本报告总结了意大利肝病学会（Italian Association for the Study of the Liver,AISF）专家小组对妊...肝脏疾病与妊娠临床上表现为相互影响的重要关系。妊娠相关性肝病是妊娠期肝损伤的最常见原因,并且对母亲和胎儿的生存构成严重威胁。本报告总结了意大利肝病学会（Italian Association for the Study of the Liver,AISF）专家小组对妊娠期肝病管理的意见,主要目的是为临床实践提供妊娠期肝脏疾病的最佳管理建议。展开更多
To investigate the expression of osteopontin （OPN） and its receptor integrin αvβ3 in the placental tissue from pregnant women complicated with preeclampsia, the expression of OPN and αvβ3 in the placenta of the ...To investigate the expression of osteopontin （OPN） and its receptor integrin αvβ3 in the placental tissue from pregnant women complicated with preeclampsia, the expression of OPN and αvβ3 in the placenta of the pregnant women with preeclampsia and healthy pregnant women was detected by immunohistochemistry, Western blotting and RT-PCR. Our results showed that OPN and αvβ3 protein were expressed in the placenta from normal pregnant woman and those with preeclampsia. OPN was located in the placental syncytiotrophoblasts and the cytoplasm of capillary endothelial cells and integrin αvβ3 was mainly expressed on the surface of trophoblast cells. Expression of OPN and integrin αvβ3 in the placental tissue from preeclampsia subjects was significantly lower than that from the control group （P〈0.05）. Compared with the control group, expression of OPN in the placental tissue from preeclampsia group was significantly lower （P〈0.05） but there was no significant difference in the expression of αv and β3 between the preeclampsia group and the controls. It is concluded that OPN and its receptor integrin αvβ3 may be involved in the pathogenesis of preeclampsia.展开更多
文摘肝脏疾病与妊娠临床上表现为相互影响的重要关系。妊娠相关性肝病是妊娠期肝损伤的最常见原因,并且对母亲和胎儿的生存构成严重威胁。本报告总结了意大利肝病学会（Italian Association for the Study of the Liver,AISF）专家小组对妊娠期肝病管理的意见,主要目的是为临床实践提供妊娠期肝脏疾病的最佳管理建议。
基金supported by a grant from Shenzhen Municipal Science and Technology Program (No 200802107)a grant for medical research programs from the Health Department of Guangdong Province (No A2009593)
文摘To investigate the expression of osteopontin （OPN） and its receptor integrin αvβ3 in the placental tissue from pregnant women complicated with preeclampsia, the expression of OPN and αvβ3 in the placenta of the pregnant women with preeclampsia and healthy pregnant women was detected by immunohistochemistry, Western blotting and RT-PCR. Our results showed that OPN and αvβ3 protein were expressed in the placenta from normal pregnant woman and those with preeclampsia. OPN was located in the placental syncytiotrophoblasts and the cytoplasm of capillary endothelial cells and integrin αvβ3 was mainly expressed on the surface of trophoblast cells. Expression of OPN and integrin αvβ3 in the placental tissue from preeclampsia subjects was significantly lower than that from the control group （P〈0.05）. Compared with the control group, expression of OPN in the placental tissue from preeclampsia group was significantly lower （P〈0.05） but there was no significant difference in the expression of αv and β3 between the preeclampsia group and the controls. It is concluded that OPN and its receptor integrin αvβ3 may be involved in the pathogenesis of preeclampsia.
