The target compound(Z)-4-[3-(4-methyl-1,2,3-thiadiazol-5-yl)-3-(4-trifluoromethylphenyl)acryloyl]morpholine was synthesized by the nucleophilic substitution,Horner-Emmons reaction,ester hydrolysis,and condensation.Its...The target compound(Z)-4-[3-(4-methyl-1,2,3-thiadiazol-5-yl)-3-(4-trifluoromethylphenyl)acryloyl]morpholine was synthesized by the nucleophilic substitution,Horner-Emmons reaction,ester hydrolysis,and condensation.Its structure was characterized by NMR,H RMS and single-crystal X-ray diffraction.The crystal of the target compound belongs to monoclinic system,space group P2_(1) with a=11.5058(15),b=6.6626(10),c=23.184(3)Å,V=1777.3(4)Å^(3),Z=8,D_(c)=1.496 Mg/m^(3),F(000)=792 andμ=0.229 mm^(–1).X-ray analysis indicated C–H....O intermolecular H-bonds in this crystal structure.The target compound exhibited 53%curative activity against TMV.展开更多
基金supported in part by Youth Natural Science Foundation of Hebei Province(No.B2019204030)the starting Scientific Research Foundation for the introduced talents of Hebei Agricultural University(Nos.201842)+1 种基金by the National Natural Science Foundation of China(Nos.31871981)Modern Agriculture Industry Technology System Innovation Team of Phase II of Hebei Province(Nos.HB2018020205)。
文摘The target compound(Z)-4-[3-(4-methyl-1,2,3-thiadiazol-5-yl)-3-(4-trifluoromethylphenyl)acryloyl]morpholine was synthesized by the nucleophilic substitution,Horner-Emmons reaction,ester hydrolysis,and condensation.Its structure was characterized by NMR,H RMS and single-crystal X-ray diffraction.The crystal of the target compound belongs to monoclinic system,space group P2_(1) with a=11.5058(15),b=6.6626(10),c=23.184(3)Å,V=1777.3(4)Å^(3),Z=8,D_(c)=1.496 Mg/m^(3),F(000)=792 andμ=0.229 mm^(–1).X-ray analysis indicated C–H....O intermolecular H-bonds in this crystal structure.The target compound exhibited 53%curative activity against TMV.
