干扰素诱导蛋白16(interferonγ-inducible protein 16,IFI16)是人类PYHIN(pyrin and HIN domain-containing protein)家族(也称干扰素诱导蛋白P200家族)成员之一,在人体器官组织中广泛存在,参与细胞周期调控、细胞衰老、细胞凋亡及免...干扰素诱导蛋白16(interferonγ-inducible protein 16,IFI16)是人类PYHIN(pyrin and HIN domain-containing protein)家族(也称干扰素诱导蛋白P200家族)成员之一,在人体器官组织中广泛存在,参与细胞周期调控、细胞衰老、细胞凋亡及免疫反应等多种生物过程。不同生理及病理状态下,IFI16的含量及定位均会发生改变,近年来研究发现,其在抗病毒、肿瘤、炎性疾病及其他多种疾病发生发展过程中可能发挥重要作用。该文对其机制及其在疾病中的研究现状进行综述,以期为深入研究IFI16提供参考。展开更多
A HPLC method was established for the determination of oleanolic acid and ursolic acid in Fructus Ligustri lucidi and Zhenqi Liyan granules. A C18 column was used with the mobile phase of methanol- water (87∶13, cont...A HPLC method was established for the determination of oleanolic acid and ursolic acid in Fructus Ligustri lucidi and Zhenqi Liyan granules. A C18 column was used with the mobile phase of methanol- water (87∶13, containing 0.2%phosphoric acid and 0.04% triethylamine) at the detection wavelength of 215nm. The calibration curves were linear in the ranges of 0.3 - 12 and 0.1 - 4μg, respectively. Theaverage recoveries were 99.2% and 97.5% in Fructus Ligustri lucidi, 97.8% and 97.4% in ZhenqiLiyan granules,respectively.展开更多
文摘干扰素诱导蛋白16(interferonγ-inducible protein 16,IFI16)是人类PYHIN(pyrin and HIN domain-containing protein)家族(也称干扰素诱导蛋白P200家族)成员之一,在人体器官组织中广泛存在,参与细胞周期调控、细胞衰老、细胞凋亡及免疫反应等多种生物过程。不同生理及病理状态下,IFI16的含量及定位均会发生改变,近年来研究发现,其在抗病毒、肿瘤、炎性疾病及其他多种疾病发生发展过程中可能发挥重要作用。该文对其机制及其在疾病中的研究现状进行综述,以期为深入研究IFI16提供参考。
文摘A HPLC method was established for the determination of oleanolic acid and ursolic acid in Fructus Ligustri lucidi and Zhenqi Liyan granules. A C18 column was used with the mobile phase of methanol- water (87∶13, containing 0.2%phosphoric acid and 0.04% triethylamine) at the detection wavelength of 215nm. The calibration curves were linear in the ranges of 0.3 - 12 and 0.1 - 4μg, respectively. Theaverage recoveries were 99.2% and 97.5% in Fructus Ligustri lucidi, 97.8% and 97.4% in ZhenqiLiyan granules,respectively.
