Skin care products with carbonic acid(H_(2)CO_(3))have gained extensive attention worldwide.However,the conversion of CO_(2) to H_(2)CO_(3) is not stable,and the mechanism of the effect of H_(2)CO_(3) on skin care has...Skin care products with carbonic acid(H_(2)CO_(3))have gained extensive attention worldwide.However,the conversion of CO_(2) to H_(2)CO_(3) is not stable,and the mechanism of the effect of H_(2)CO_(3) on skin care has not been clearly proved.The hydration-dissolution behaviors of CO_(2) were investigated under different temperature,pH,and pressure conditions.Moreover,based on the phenomenon of CO_(2) hydration transformation,the inflammatory effect of CO_(2) hydrate on macrophages(RAW 264.7)was investigated.The result shows that the increase in temperature weakened the hydration of CO_(2),and the increase in pH and pressure both promoted the water-phase transformation of CO_(2).When pH<6,CO_(2) reacts with water to generate H_(2)CO_(3).When pH was between 6-7,the prompt solution was a mixture of H_(2)CO_(3) and HCO_(3)^(-).When the pH was between 7-9,they mainly generated HCO_(3)^(-).And when pH>9,CO_(2) solubility mainly converts to CO_(3)^(2-).Besides,CO_(2) can inhibit the secretion of inflammatory factors by RAW 264.7 cells by inhibiting the phosphorylation of the p38 protein.CO_(2) hydrate inhibited the expression of pro-inflammatory factors IL-6,TNF-α,and up-regulated the expression of anti-inflammatory factor IL-10.Furthermore,the anti-inflammatory molecular mechanism of CO_(2) hydration inhibited the MAPK signaling pathway by inhibiting the phosphorylation of p38.The hydration-dissolution behavior of CO_(2) was investigated.This work revealed the anti-inflammatory bioeffect of CO_(2) hydrate,providing a theoretical basis and application support for CO_(2) skin care products.展开更多
通过考察不同地区、不同年龄和不同性别受试者唇部皮肤基础状态,进行唇部生理参数的多维度分析和研究,并通过唇油对唇部皮肤的干预,来探究影响唇部皮肤性状的主要因素。用无创性评价方法测定了华东地区(73名)和华北地区(50名)受试者(18...通过考察不同地区、不同年龄和不同性别受试者唇部皮肤基础状态,进行唇部生理参数的多维度分析和研究,并通过唇油对唇部皮肤的干预,来探究影响唇部皮肤性状的主要因素。用无创性评价方法测定了华东地区(73名)和华北地区(50名)受试者(18~35岁73名,35~60岁50名;男性55名,女性68名)唇部下唇的水分含量、TEWL、光泽度、弹性、L^(*)a^(*)b^(*)值和纹理8个皮肤生理参数。研究结果表明,华东地区组受试者唇部基础状态的经皮水分散失(Trans Epidermal Water Loss,TEWL)值(51.99±17.37)、L*值(51.99±8.83)、b*值(15.40±1.56)和纹理值(15.10±6.43)分别显著高于华北地区组(P<0.05)。35~60岁组受试者唇部基础状态的水分含量(56.82±12.63)和皮肤弹性(0.78±0.18)显著高于18~35岁组(P<0.05)。男性组唇部基础状态的TEWL值(52.08±17.68)显著高于女性组(43.48±16.03)(P<0.05)。通过唇油对唇部皮肤的干预,与基础状态相比,受试者使用唇油后其唇部水分含量均是先降低后逐渐升高;TEWL值先显著性降低后逐渐增加;光泽度、弹性和纹理均是先增加后减小;皮肤色泽(L^(*)a^(*)b^(*)值)的变化不显著。由此可知,受试者唇部皮肤生理参数不仅受到地区、年龄以及性别的影响,还与受试者唇部基础状态及唇部产品的使用频率等因素相关。展开更多
文摘Skin care products with carbonic acid(H_(2)CO_(3))have gained extensive attention worldwide.However,the conversion of CO_(2) to H_(2)CO_(3) is not stable,and the mechanism of the effect of H_(2)CO_(3) on skin care has not been clearly proved.The hydration-dissolution behaviors of CO_(2) were investigated under different temperature,pH,and pressure conditions.Moreover,based on the phenomenon of CO_(2) hydration transformation,the inflammatory effect of CO_(2) hydrate on macrophages(RAW 264.7)was investigated.The result shows that the increase in temperature weakened the hydration of CO_(2),and the increase in pH and pressure both promoted the water-phase transformation of CO_(2).When pH<6,CO_(2) reacts with water to generate H_(2)CO_(3).When pH was between 6-7,the prompt solution was a mixture of H_(2)CO_(3) and HCO_(3)^(-).When the pH was between 7-9,they mainly generated HCO_(3)^(-).And when pH>9,CO_(2) solubility mainly converts to CO_(3)^(2-).Besides,CO_(2) can inhibit the secretion of inflammatory factors by RAW 264.7 cells by inhibiting the phosphorylation of the p38 protein.CO_(2) hydrate inhibited the expression of pro-inflammatory factors IL-6,TNF-α,and up-regulated the expression of anti-inflammatory factor IL-10.Furthermore,the anti-inflammatory molecular mechanism of CO_(2) hydration inhibited the MAPK signaling pathway by inhibiting the phosphorylation of p38.The hydration-dissolution behavior of CO_(2) was investigated.This work revealed the anti-inflammatory bioeffect of CO_(2) hydrate,providing a theoretical basis and application support for CO_(2) skin care products.
文摘通过考察不同地区、不同年龄和不同性别受试者唇部皮肤基础状态,进行唇部生理参数的多维度分析和研究,并通过唇油对唇部皮肤的干预,来探究影响唇部皮肤性状的主要因素。用无创性评价方法测定了华东地区(73名)和华北地区(50名)受试者(18~35岁73名,35~60岁50名;男性55名,女性68名)唇部下唇的水分含量、TEWL、光泽度、弹性、L^(*)a^(*)b^(*)值和纹理8个皮肤生理参数。研究结果表明,华东地区组受试者唇部基础状态的经皮水分散失(Trans Epidermal Water Loss,TEWL)值(51.99±17.37)、L*值(51.99±8.83)、b*值(15.40±1.56)和纹理值(15.10±6.43)分别显著高于华北地区组(P<0.05)。35~60岁组受试者唇部基础状态的水分含量(56.82±12.63)和皮肤弹性(0.78±0.18)显著高于18~35岁组(P<0.05)。男性组唇部基础状态的TEWL值(52.08±17.68)显著高于女性组(43.48±16.03)(P<0.05)。通过唇油对唇部皮肤的干预,与基础状态相比,受试者使用唇油后其唇部水分含量均是先降低后逐渐升高;TEWL值先显著性降低后逐渐增加;光泽度、弹性和纹理均是先增加后减小;皮肤色泽(L^(*)a^(*)b^(*)值)的变化不显著。由此可知,受试者唇部皮肤生理参数不仅受到地区、年龄以及性别的影响,还与受试者唇部基础状态及唇部产品的使用频率等因素相关。
