cGAS-STING信号通路是固有免疫系统的重要组成部分,可以触发以Ⅰ型干扰素(interferon type 1,IFN-1)为代表的一系列炎症因子的表达,其在感染性疾病、自身免疫性疾病及肿瘤等多种疾病中发挥着重要作用.近年来,研究发现cGAS-STING信号通...cGAS-STING信号通路是固有免疫系统的重要组成部分,可以触发以Ⅰ型干扰素(interferon type 1,IFN-1)为代表的一系列炎症因子的表达,其在感染性疾病、自身免疫性疾病及肿瘤等多种疾病中发挥着重要作用.近年来,研究发现cGAS-STING信号通路与肝脏疾病的进展密切相关.本文就cGAS-STING信号通路在慢性乙型肝炎、酒精性肝病、非酒精性脂肪性肝病、肝癌等常见肝脏疾病中的作用及其在肝脏疾病治疗中的应用现状作一综述.展开更多
Objective To observe the efficacy of treating tinnitus with electrical stimulation on acupoint in the distribution area of ear vagus nerve by combining with sound masking. Methods Sixty-three volunteers suffering from...Objective To observe the efficacy of treating tinnitus with electrical stimulation on acupoint in the distribution area of ear vagus nerve by combining with sound masking. Methods Sixty-three volunteers suffering from tinnitus were randomly divided into a treatment group （32 cases） and a control group （31 cases） according to envelope method. The treatment group was given the treatment with electrical stimulation on acupoint in the distribution area of ear vagus nerve by combining with sound masking while the control group was given the treatment by taking flunarizine hydrochloride capsules and oryzanol orally. The treatment for both groups lasted for eight weeks. The efficacy was evaluated before treatment, 4 weeks and 8 weeks following the treatment respectively according to ＂Tinnitus Handicap Inventory＂ and ＂Tinnitus Dysphoria Inventory＂. Results It was revealed from the Tinnitus Handicap Inventory that the differences were not statistically significant by comparing the two groups after treatment for 4 weeks （χ2=1.981, P=0.16）; After 8 weeks of the treatment, patients with mild tinnitus and severe tinnitus were significantly improved in the treatment group compared with those before treatment （χ2=25.01, P〈0.O01） while the difference in the control group was not statistically significant before and after treatment （χ2=2.986, P=0.084）, and the difference of the ratio of patients with mild tinnitus in the two groups was statistically significant （χ2=9.315, P=0.002）. It was revealed from the Tinnitus Dysphoria Inventory that dysphoria of patients in the treatment group was more alleviated than that in the control group after treatment for 4 weeks （χ2=4.661, P=0.03）; After 8 weeks of the treatment, the patients with mild dysphoria and severe dysphoria were significantly improved in the two groups （χ2=25.397, P〈O.001 and χ2=7.828, P=O.O05, respectively）, and the efficacy in the treatment group was improved more significantly than that in the control group （χ2=5.857, P=0.016）. It was shown from the comprehensive efficacy that after 8 weeks of treatment, the effective rates of the two groups were 90.63% （29/32） and 80.65% （25/31） respectively, and the difference between the two groups was not statistically significant （χ2=0.595, P=0.44）. Conclusion Handicap and dysphoria of tinnitus can be improved significantly by treating with electrical stimulation on acupoint in the distribution area of ear vagus nerve and sound masking, and the efficacy was superior to that of western medicines.展开更多
文摘cGAS-STING信号通路是固有免疫系统的重要组成部分,可以触发以Ⅰ型干扰素(interferon type 1,IFN-1)为代表的一系列炎症因子的表达,其在感染性疾病、自身免疫性疾病及肿瘤等多种疾病中发挥着重要作用.近年来,研究发现cGAS-STING信号通路与肝脏疾病的进展密切相关.本文就cGAS-STING信号通路在慢性乙型肝炎、酒精性肝病、非酒精性脂肪性肝病、肝癌等常见肝脏疾病中的作用及其在肝脏疾病治疗中的应用现状作一综述.
文摘Objective To observe the efficacy of treating tinnitus with electrical stimulation on acupoint in the distribution area of ear vagus nerve by combining with sound masking. Methods Sixty-three volunteers suffering from tinnitus were randomly divided into a treatment group （32 cases） and a control group （31 cases） according to envelope method. The treatment group was given the treatment with electrical stimulation on acupoint in the distribution area of ear vagus nerve by combining with sound masking while the control group was given the treatment by taking flunarizine hydrochloride capsules and oryzanol orally. The treatment for both groups lasted for eight weeks. The efficacy was evaluated before treatment, 4 weeks and 8 weeks following the treatment respectively according to ＂Tinnitus Handicap Inventory＂ and ＂Tinnitus Dysphoria Inventory＂. Results It was revealed from the Tinnitus Handicap Inventory that the differences were not statistically significant by comparing the two groups after treatment for 4 weeks （χ2=1.981, P=0.16）; After 8 weeks of the treatment, patients with mild tinnitus and severe tinnitus were significantly improved in the treatment group compared with those before treatment （χ2=25.01, P〈0.O01） while the difference in the control group was not statistically significant before and after treatment （χ2=2.986, P=0.084）, and the difference of the ratio of patients with mild tinnitus in the two groups was statistically significant （χ2=9.315, P=0.002）. It was revealed from the Tinnitus Dysphoria Inventory that dysphoria of patients in the treatment group was more alleviated than that in the control group after treatment for 4 weeks （χ2=4.661, P=0.03）; After 8 weeks of the treatment, the patients with mild dysphoria and severe dysphoria were significantly improved in the two groups （χ2=25.397, P〈O.001 and χ2=7.828, P=O.O05, respectively）, and the efficacy in the treatment group was improved more significantly than that in the control group （χ2=5.857, P=0.016）. It was shown from the comprehensive efficacy that after 8 weeks of treatment, the effective rates of the two groups were 90.63% （29/32） and 80.65% （25/31） respectively, and the difference between the two groups was not statistically significant （χ2=0.595, P=0.44）. Conclusion Handicap and dysphoria of tinnitus can be improved significantly by treating with electrical stimulation on acupoint in the distribution area of ear vagus nerve and sound masking, and the efficacy was superior to that of western medicines.
