目的 观察智能镜像手套任务导向性训练联合低频重复经颅磁刺激(rTMS)对脑卒中患者手功能恢复的效果。方法 2022年10月1日至2023年6月30日,选择苏北人民医院脑卒中患者136例,随机分为对照组、镜像组、rTMS组和联合组,每组34例。各组均给...目的 观察智能镜像手套任务导向性训练联合低频重复经颅磁刺激(rTMS)对脑卒中患者手功能恢复的效果。方法 2022年10月1日至2023年6月30日,选择苏北人民医院脑卒中患者136例,随机分为对照组、镜像组、rTMS组和联合组,每组34例。各组均给予常规康复治疗,镜像组增加智能镜像手套任务导向性训练治疗,rTMS组增加低频rTMS治疗,联合组增加智能镜像手套任务导向性训练与低频rTMS治疗,共4周。比较治疗前后Fugl-Meyer评定量表上肢部分(FMA-UE)评分、Wolf运动功能测定量表(WMFT)评分和前臂伸肌群、屈肌群表面肌电均方根值(RMS)患侧/健侧比值;比较rTMS组和联合组治疗前后经颅磁刺激运动诱发电位(MEP)的差异。结果 对照组4例、镜像组7例、rTMS组5例、联合组6例脱落。4组FMA-UE、WMFT评分和前臂伸肌、屈肌群RMS比的组内效应(F> 996.656, P <0.001)、组间效应(F> 20.333, P <0.001)和交互效应(F> 72.796, P <0.001)均显著,且联合组最优。治疗后,rTMS组和联合组MEP的振幅均增加(|t|> 3.842, P <0.05),联合组明显高于rTMS组(t=-3.060, P <0.01)。结论 智能镜像手套任务导向性训练联合低频rTMS可有效促进脑卒中患者手功能恢复。展开更多
As an important protective group of amines and amino acids,tert-butoxycarbonyl(Boc) group was extensively used in organic synthesis.Though many mild and selective reagents could be used,there is still a need for the d...As an important protective group of amines and amino acids,tert-butoxycarbonyl(Boc) group was extensively used in organic synthesis.Though many mild and selective reagents could be used,there is still a need for the development of a more simple and convenient method for deprotection.In this paper,a new method for the deprotection of N-Boc group with silica gel in refluxing toluene was reported.The reactions were mostly achieved in 5 h with high yields(75%-98%).N-Boc protected indoline and benzylamine,which are not deprotected with other mild method,could be deprotected with our method in good yields(89% and 95%,respectively).Additionally the deprotection of other carbamates such as Cbz,Fmoc and ethyl carbamate wasn′t observed under same conditions.展开更多
文摘目的 观察智能镜像手套任务导向性训练联合低频重复经颅磁刺激(rTMS)对脑卒中患者手功能恢复的效果。方法 2022年10月1日至2023年6月30日,选择苏北人民医院脑卒中患者136例,随机分为对照组、镜像组、rTMS组和联合组,每组34例。各组均给予常规康复治疗,镜像组增加智能镜像手套任务导向性训练治疗,rTMS组增加低频rTMS治疗,联合组增加智能镜像手套任务导向性训练与低频rTMS治疗,共4周。比较治疗前后Fugl-Meyer评定量表上肢部分(FMA-UE)评分、Wolf运动功能测定量表(WMFT)评分和前臂伸肌群、屈肌群表面肌电均方根值(RMS)患侧/健侧比值;比较rTMS组和联合组治疗前后经颅磁刺激运动诱发电位(MEP)的差异。结果 对照组4例、镜像组7例、rTMS组5例、联合组6例脱落。4组FMA-UE、WMFT评分和前臂伸肌、屈肌群RMS比的组内效应(F> 996.656, P <0.001)、组间效应(F> 20.333, P <0.001)和交互效应(F> 72.796, P <0.001)均显著,且联合组最优。治疗后,rTMS组和联合组MEP的振幅均增加(|t|> 3.842, P <0.05),联合组明显高于rTMS组(t=-3.060, P <0.01)。结论 智能镜像手套任务导向性训练联合低频rTMS可有效促进脑卒中患者手功能恢复。
文摘As an important protective group of amines and amino acids,tert-butoxycarbonyl(Boc) group was extensively used in organic synthesis.Though many mild and selective reagents could be used,there is still a need for the development of a more simple and convenient method for deprotection.In this paper,a new method for the deprotection of N-Boc group with silica gel in refluxing toluene was reported.The reactions were mostly achieved in 5 h with high yields(75%-98%).N-Boc protected indoline and benzylamine,which are not deprotected with other mild method,could be deprotected with our method in good yields(89% and 95%,respectively).Additionally the deprotection of other carbamates such as Cbz,Fmoc and ethyl carbamate wasn′t observed under same conditions.
