丹桂飘香,千里寄相思;明月婵娟,天涯共此时。为促进国内外治疗药物监测及临床毒理学(therapeutic drug monitoring and clinical toxicology,TDMCT)工作的交流与合作,推动我国TDMCT工作与科研的发展,由国际治疗药物监测和临床毒理学会(I...丹桂飘香,千里寄相思;明月婵娟,天涯共此时。为促进国内外治疗药物监测及临床毒理学(therapeutic drug monitoring and clinical toxicology,TDMCT)工作的交流与合作,推动我国TDMCT工作与科研的发展,由国际治疗药物监测和临床毒理学会(IATDMCT)及北京大学治疗药物监测和临床毒理(TDMCT)中心共同主办,北京大学第三医院、北京大学第一医院共同承办的"2010北京国际治疗药物监测和临床毒理学术会议"于2010年9月23—25日在京召开。北京大学常务副校长柯杨出席开幕式并致辞,中国药学会副理事长李大魁、北京大学第三医院院长陈仲强、北京大学第一医院院长刘玉村等领导和嘉宾出席了大会开幕式。本届会议以"Better TDM,Better Treatment"为主题,共邀请到包括现任、候任IATDMCT主席,日本TDM协会主席在内的14名国际讲者,以及周宏灏院士等13名国内讲者,到会为大家带来TDMCT领域最新进展的精彩讲演。本届会议得到了国内同道的热情关注及积极参与,虽值中秋佳节假期,依然有近400名全国各地的药学、临床工作者参会。为飨读者需求,本刊将纪要总结如下,提请关注。展开更多
Aim To study the pharmacokinetics of remifentanil in Chinese aduh patients undergoing elective surgery and compare the results with the data already published. Methods The pharmacokinetics of remifentanil was determin...Aim To study the pharmacokinetics of remifentanil in Chinese aduh patients undergoing elective surgery and compare the results with the data already published. Methods The pharmacokinetics of remifentanil was determined in 10 aduh patients undergoing elective surgery. Remifentanil 5 - 6 μg·kg^-1 was administered within 1 min after the induction of anesthesia. One point five millilitre of arterial blood samples were collected at 0 （baseline）, 1,2, 3, 5,7, 10, 15, 20, 25, 30, 45, 60, and 90 min after drug administration. Remifentanil concentration was assayed by HPLC/MS/MS. Resuits The concentration-time course of remifentanil was best described by a two-compartment model. Total clearance （CL = 2. 149 ± 0. 431 L·min^-1） of remifentanil was greater than the normal hepatic blood flow. The distribution half-life （t1/2α） [ 1.56 ± 0. 52 min （0.73 - 2.31 ） ] and the elimination half-life （t1/2β） [22.07 ± 10.30 min （9, 71 -36.07）] were similar with those in previous reports. Volume of distribution （ Vd = 65. 766 ± 29. 100 L） was about two times greater than that reported in previous studies of other ethnics. Conclusion In the present study, the volume of distribution is significantly greater than thai reported in previous studies of other ethnics, indicating that there are some differences in the pharmacokinetics of remifentanil among different ethnics.展开更多
文摘丹桂飘香,千里寄相思;明月婵娟,天涯共此时。为促进国内外治疗药物监测及临床毒理学(therapeutic drug monitoring and clinical toxicology,TDMCT)工作的交流与合作,推动我国TDMCT工作与科研的发展,由国际治疗药物监测和临床毒理学会(IATDMCT)及北京大学治疗药物监测和临床毒理(TDMCT)中心共同主办,北京大学第三医院、北京大学第一医院共同承办的"2010北京国际治疗药物监测和临床毒理学术会议"于2010年9月23—25日在京召开。北京大学常务副校长柯杨出席开幕式并致辞,中国药学会副理事长李大魁、北京大学第三医院院长陈仲强、北京大学第一医院院长刘玉村等领导和嘉宾出席了大会开幕式。本届会议以"Better TDM,Better Treatment"为主题,共邀请到包括现任、候任IATDMCT主席,日本TDM协会主席在内的14名国际讲者,以及周宏灏院士等13名国内讲者,到会为大家带来TDMCT领域最新进展的精彩讲演。本届会议得到了国内同道的热情关注及积极参与,虽值中秋佳节假期,依然有近400名全国各地的药学、临床工作者参会。为飨读者需求,本刊将纪要总结如下,提请关注。
文摘Aim To study the pharmacokinetics of remifentanil in Chinese aduh patients undergoing elective surgery and compare the results with the data already published. Methods The pharmacokinetics of remifentanil was determined in 10 aduh patients undergoing elective surgery. Remifentanil 5 - 6 μg·kg^-1 was administered within 1 min after the induction of anesthesia. One point five millilitre of arterial blood samples were collected at 0 （baseline）, 1,2, 3, 5,7, 10, 15, 20, 25, 30, 45, 60, and 90 min after drug administration. Remifentanil concentration was assayed by HPLC/MS/MS. Resuits The concentration-time course of remifentanil was best described by a two-compartment model. Total clearance （CL = 2. 149 ± 0. 431 L·min^-1） of remifentanil was greater than the normal hepatic blood flow. The distribution half-life （t1/2α） [ 1.56 ± 0. 52 min （0.73 - 2.31 ） ] and the elimination half-life （t1/2β） [22.07 ± 10.30 min （9, 71 -36.07）] were similar with those in previous reports. Volume of distribution （ Vd = 65. 766 ± 29. 100 L） was about two times greater than that reported in previous studies of other ethnics. Conclusion In the present study, the volume of distribution is significantly greater than thai reported in previous studies of other ethnics, indicating that there are some differences in the pharmacokinetics of remifentanil among different ethnics.
