WWOX基因位于染色体16q23．3—24．1区域，并跨越了整个常见染色体脆性位点FRA16D。在普通型脆性位点FRA16D上的新基因WWOX已被认为是与多种肿瘤相关的抑癌基因，其DNA序列，mRNA、蛋白结构已基本清楚，其促凋亡的作用已经肯定，然而具...WWOX基因位于染色体16q23．3—24．1区域，并跨越了整个常见染色体脆性位点FRA16D。在普通型脆性位点FRA16D上的新基因WWOX已被认为是与多种肿瘤相关的抑癌基因，其DNA序列，mRNA、蛋白结构已基本清楚，其促凋亡的作用已经肯定，然而具体的作用机制存在着争议。WWOX基因的外显子丢失，杂合性缺失（loss of heterozygosity，LOH）及蛋白表达异常在多种肿瘤中频发出现。展开更多
A study of the electrochemical reduction behavior of safranine T by means of electrochemical methods coupled with ESR （electron spin resonance） is presented. Through an "in situ" tracing of the 1-electron ...A study of the electrochemical reduction behavior of safranine T by means of electrochemical methods coupled with ESR （electron spin resonance） is presented. Through an "in situ" tracing of the 1-electron reduction intermediate—free radical, the structure of the free radical has been deduced. During the electrochemical reduction the free radical went through a post-electrolysis chemical decay including parallel steps of zero and first order reactions. This fact gives further support and experimental ascertainment of the viewpoint that some electrode processes are clearly related to the enzymatic catalyses<sup>[1]</sup>. In accordance with the chemical behavior of safranine T free radicals at various concentrations and at different potentials the authors have advanced a scheme of reaction mechanism and evaluated the kinetic parameters of the reation steps by simulating the experimental curves.展开更多
文摘WWOX基因位于染色体16q23．3—24．1区域，并跨越了整个常见染色体脆性位点FRA16D。在普通型脆性位点FRA16D上的新基因WWOX已被认为是与多种肿瘤相关的抑癌基因，其DNA序列，mRNA、蛋白结构已基本清楚，其促凋亡的作用已经肯定，然而具体的作用机制存在着争议。WWOX基因的外显子丢失，杂合性缺失（loss of heterozygosity，LOH）及蛋白表达异常在多种肿瘤中频发出现。
基金Project supported by the National Natural Science Foundation of China.
文摘A study of the electrochemical reduction behavior of safranine T by means of electrochemical methods coupled with ESR （electron spin resonance） is presented. Through an "in situ" tracing of the 1-electron reduction intermediate—free radical, the structure of the free radical has been deduced. During the electrochemical reduction the free radical went through a post-electrolysis chemical decay including parallel steps of zero and first order reactions. This fact gives further support and experimental ascertainment of the viewpoint that some electrode processes are clearly related to the enzymatic catalyses<sup>[1]</sup>. In accordance with the chemical behavior of safranine T free radicals at various concentrations and at different potentials the authors have advanced a scheme of reaction mechanism and evaluated the kinetic parameters of the reation steps by simulating the experimental curves.
