为了保障草甘膦生产企业的安全生产,降低或避免其生产过程中火灾爆炸类安全事故的发生,拟采用改进的道化学火灾爆炸危险指数评价法(DOW法)对其进行安全评价。针对现行通用DOW法中安全措施系数计算不够准确的问题,增加人员安全补偿系数,...为了保障草甘膦生产企业的安全生产,降低或避免其生产过程中火灾爆炸类安全事故的发生,拟采用改进的道化学火灾爆炸危险指数评价法(DOW法)对其进行安全评价。针对现行通用DOW法中安全措施系数计算不够准确的问题,增加人员安全补偿系数,并将安全补偿划分为预防事件发生型和缓解后果型,再对危险工艺单元进行定量分析和计算,从而提高DOW法安全评价结果的准确性。将改进的DOW法应用于某草甘膦生产企业的安全评价,结果发现,改进后的DOW法在火灾爆炸危险指数(Fire and Explosion Risk Index,F&EI)与暴露面积数值的测定上更灵敏,能更准确地反映草甘膦企业火灾爆炸的安全评价结果。展开更多
To guide the molecular design of the pH-sensitive triblock amphiphilic polymer MPEG-PAE-PLA and the for- mula design of its doxorubicine （DOX）-loaded micelles, dissipative particle dynamics （DPD） simulations are e...To guide the molecular design of the pH-sensitive triblock amphiphilic polymer MPEG-PAE-PLA and the for- mula design of its doxorubicine （DOX）-loaded micelles, dissipative particle dynamics （DPD） simulations are em- ployed to investigate the aggregation behaviors of the DOX-loaded micelles. The simulation results showed that the aggregate morphologies of micelles and DOX distribution are influenced by degree of polymerization of blocks, and the proposed structure of polymer is MPEG44-PAE3-PLA4. With different contents of polymer or DOX, differ- ent aggregate morphologies of the micelles, like microsphere, spindle/column, reticulation or lamella are observed. To prepare the micro-spherical DOX-loaded micelles, the polymer content is proposed as 10%--15%, and the DOX content less than 10%.展开更多
文摘为了保障草甘膦生产企业的安全生产,降低或避免其生产过程中火灾爆炸类安全事故的发生,拟采用改进的道化学火灾爆炸危险指数评价法(DOW法)对其进行安全评价。针对现行通用DOW法中安全措施系数计算不够准确的问题,增加人员安全补偿系数,并将安全补偿划分为预防事件发生型和缓解后果型,再对危险工艺单元进行定量分析和计算,从而提高DOW法安全评价结果的准确性。将改进的DOW法应用于某草甘膦生产企业的安全评价,结果发现,改进后的DOW法在火灾爆炸危险指数(Fire and Explosion Risk Index,F&EI)与暴露面积数值的测定上更灵敏,能更准确地反映草甘膦企业火灾爆炸的安全评价结果。
文摘To guide the molecular design of the pH-sensitive triblock amphiphilic polymer MPEG-PAE-PLA and the for- mula design of its doxorubicine （DOX）-loaded micelles, dissipative particle dynamics （DPD） simulations are em- ployed to investigate the aggregation behaviors of the DOX-loaded micelles. The simulation results showed that the aggregate morphologies of micelles and DOX distribution are influenced by degree of polymerization of blocks, and the proposed structure of polymer is MPEG44-PAE3-PLA4. With different contents of polymer or DOX, differ- ent aggregate morphologies of the micelles, like microsphere, spindle/column, reticulation or lamella are observed. To prepare the micro-spherical DOX-loaded micelles, the polymer content is proposed as 10%--15%, and the DOX content less than 10%.
